Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence

Vadym Shypulin; Oksana Stoliarova; Volodymyr Konovalenko; Oleksiy Tatskyy; Gennadiy Didenko; Sergii Konovalenko

doi:doi:10.11648/j.ajbls.20190704.11

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Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence

Vadym Shypulin, Oksana Stoliarova, Volodymyr Konovalenko, Oleksiy Tatskyy, Gennadiy Didenko, Sergii Konovalenko

Published in American Journal of Biomedical and Life Sciences (Volume 7, Issue 4)

Received: 20 June 2019 Accepted: 22 July 2019 Published: 6 August 2019

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Abstract

An article deals with the influence of the transforming growth factor beta-1 (TGF-β1) on the carcinogenesis of hepatic cells, as well as attention is given to the role of this factor in the hepatocellular carcinoma (HCC) progression. We monitored two groups of patients: in the treatment group, patients were administered cancer vaccine therapy and anti-relapse immune corrector Arecur® – a complex of exogenous peptides with anti-inflammatory, anti-infective and regenerating properties; in the reference group, patients were not administered immune corrector. The study showed that the cancer vaccine has a positive effect on the activity of T-cell immunity and interleukin-2 expression level. The result of the inclusion of anti-relapse immune corrector Arecur® in the patients’ management regimen was the reduction of TGF-β1 expression. The lower recurrence rate of HCC in the treatment group suggests that Arecur® may prevent possible recurrences and metastasis of HCC by limiting TGF-β1 expression. Future researches of anti-relapse immune correction regimens for patients with hepatic tumours may improve the therapeutic strategy and prevention of the disease progression in the long term. In addition, immune correction using exogenous peptides is likely capable of preventing the malignancy in patients with chronic hepatitis and liver cirrhosis.

Published in	American Journal of Biomedical and Life Sciences (Volume 7, Issue 4)
DOI	10.11648/j.ajbls.20190704.11
Page(s)	73-78
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Hepatitis, TGF-β1, Hepatocellular Carcinoma, Anti-relapse Immune Correction, Exogenous Peptides

References

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APA Style

Vadym Shypulin, Oksana Stoliarova, Volodymyr Konovalenko, Oleksiy Tatskyy, Gennadiy Didenko, et al. (2019). Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence. American Journal of Biomedical and Life Sciences, 7(4), 73-78. https://doi.org/10.11648/j.ajbls.20190704.11

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ACS Style

Vadym Shypulin; Oksana Stoliarova; Volodymyr Konovalenko; Oleksiy Tatskyy; Gennadiy Didenko, et al. Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence. Am. J. Biomed. Life Sci. 2019, 7(4), 73-78. doi: 10.11648/j.ajbls.20190704.11

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AMA Style

Vadym Shypulin, Oksana Stoliarova, Volodymyr Konovalenko, Oleksiy Tatskyy, Gennadiy Didenko, et al. Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence. Am J Biomed Life Sci. 2019;7(4):73-78. doi: 10.11648/j.ajbls.20190704.11

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@article{10.11648/j.ajbls.20190704.11,
  author = {Vadym Shypulin and Oksana Stoliarova and Volodymyr Konovalenko and Oleksiy Tatskyy and Gennadiy Didenko and Sergii Konovalenko},
  title = {Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {7},
  number = {4},
  pages = {73-78},
  doi = {10.11648/j.ajbls.20190704.11},
  url = {https://doi.org/10.11648/j.ajbls.20190704.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20190704.11},
  abstract = {An article deals with the influence of the transforming growth factor beta-1 (TGF-β1) on the carcinogenesis of hepatic cells, as well as attention is given to the role of this factor in the hepatocellular carcinoma (HCC) progression. We monitored two groups of patients: in the treatment group, patients were administered cancer vaccine therapy and anti-relapse immune corrector Arecur® – a complex of exogenous peptides with anti-inflammatory, anti-infective and regenerating properties; in the reference group, patients were not administered immune corrector. The study showed that the cancer vaccine has a positive effect on the activity of T-cell immunity and interleukin-2 expression level. The result of the inclusion of anti-relapse immune corrector Arecur® in the patients’ management regimen was the reduction of TGF-β1 expression. The lower recurrence rate of HCC in the treatment group suggests that Arecur® may prevent possible recurrences and metastasis of HCC by limiting TGF-β1 expression. Future researches of anti-relapse immune correction regimens for patients with hepatic tumours may improve the therapeutic strategy and prevention of the disease progression in the long term. In addition, immune correction using exogenous peptides is likely capable of preventing the malignancy in patients with chronic hepatitis and liver cirrhosis.},
 year = {2019}
}

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TY  - JOUR
T1  - Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence
AU  - Vadym Shypulin
AU  - Oksana Stoliarova
AU  - Volodymyr Konovalenko
AU  - Oleksiy Tatskyy
AU  - Gennadiy Didenko
AU  - Sergii Konovalenko
Y1  - 2019/08/06
PY  - 2019
N1  - https://doi.org/10.11648/j.ajbls.20190704.11
DO  - 10.11648/j.ajbls.20190704.11
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 73
EP  - 78
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20190704.11
AB  - An article deals with the influence of the transforming growth factor beta-1 (TGF-β1) on the carcinogenesis of hepatic cells, as well as attention is given to the role of this factor in the hepatocellular carcinoma (HCC) progression. We monitored two groups of patients: in the treatment group, patients were administered cancer vaccine therapy and anti-relapse immune corrector Arecur® – a complex of exogenous peptides with anti-inflammatory, anti-infective and regenerating properties; in the reference group, patients were not administered immune corrector. The study showed that the cancer vaccine has a positive effect on the activity of T-cell immunity and interleukin-2 expression level. The result of the inclusion of anti-relapse immune corrector Arecur® in the patients’ management regimen was the reduction of TGF-β1 expression. The lower recurrence rate of HCC in the treatment group suggests that Arecur® may prevent possible recurrences and metastasis of HCC by limiting TGF-β1 expression. Future researches of anti-relapse immune correction regimens for patients with hepatic tumours may improve the therapeutic strategy and prevention of the disease progression in the long term. In addition, immune correction using exogenous peptides is likely capable of preventing the malignancy in patients with chronic hepatitis and liver cirrhosis.
VL  - 7
IS  - 4
ER  -

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Author Information

Vadym Shypulin

Department of Internal Diseases, Bogomolets National Medical University, Kyiv, Ukraine
Oksana Stoliarova

Department of Radiology, National Cancer Institute of the MoH of Ukraine, Kyiv, Ukraine
Volodymyr Konovalenko

Department of Oncoimmunology and Antitumor Vaccine Engineering, RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Oleksiy Tatskyy

Department of Scientific Research, International Institute of Biotherapy, Kyiv, Ukraine
Gennadiy Didenko

Department of Oncoimmunology and Antitumor Vaccine Engineering, RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Sergii Konovalenko

Department of Scientific Research, International Institute of Biotherapy, Kyiv, Ukraine

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APA Style

Vadym Shypulin, Oksana Stoliarova, Volodymyr Konovalenko, Oleksiy Tatskyy, Gennadiy Didenko, et al. (2019). Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence. American Journal of Biomedical and Life Sciences, 7(4), 73-78. https://doi.org/10.11648/j.ajbls.20190704.11

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ACS Style

Vadym Shypulin; Oksana Stoliarova; Volodymyr Konovalenko; Oleksiy Tatskyy; Gennadiy Didenko, et al. Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence. Am. J. Biomed. Life Sci. 2019, 7(4), 73-78. doi: 10.11648/j.ajbls.20190704.11

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AMA Style

Vadym Shypulin, Oksana Stoliarova, Volodymyr Konovalenko, Oleksiy Tatskyy, Gennadiy Didenko, et al. Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence. Am J Biomed Life Sci. 2019;7(4):73-78. doi: 10.11648/j.ajbls.20190704.11

Copy | Download

@article{10.11648/j.ajbls.20190704.11,
  author = {Vadym Shypulin and Oksana Stoliarova and Volodymyr Konovalenko and Oleksiy Tatskyy and Gennadiy Didenko and Sergii Konovalenko},
  title = {Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {7},
  number = {4},
  pages = {73-78},
  doi = {10.11648/j.ajbls.20190704.11},
  url = {https://doi.org/10.11648/j.ajbls.20190704.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20190704.11},
  abstract = {An article deals with the influence of the transforming growth factor beta-1 (TGF-β1) on the carcinogenesis of hepatic cells, as well as attention is given to the role of this factor in the hepatocellular carcinoma (HCC) progression. We monitored two groups of patients: in the treatment group, patients were administered cancer vaccine therapy and anti-relapse immune corrector Arecur® – a complex of exogenous peptides with anti-inflammatory, anti-infective and regenerating properties; in the reference group, patients were not administered immune corrector. The study showed that the cancer vaccine has a positive effect on the activity of T-cell immunity and interleukin-2 expression level. The result of the inclusion of anti-relapse immune corrector Arecur® in the patients’ management regimen was the reduction of TGF-β1 expression. The lower recurrence rate of HCC in the treatment group suggests that Arecur® may prevent possible recurrences and metastasis of HCC by limiting TGF-β1 expression. Future researches of anti-relapse immune correction regimens for patients with hepatic tumours may improve the therapeutic strategy and prevention of the disease progression in the long term. In addition, immune correction using exogenous peptides is likely capable of preventing the malignancy in patients with chronic hepatitis and liver cirrhosis.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Study of the Exogenous Peptide Effect on the TGF-β1 Expression – A Risk Factor for the Hepatocellular Carcinoma Recurrence
AU  - Vadym Shypulin
AU  - Oksana Stoliarova
AU  - Volodymyr Konovalenko
AU  - Oleksiy Tatskyy
AU  - Gennadiy Didenko
AU  - Sergii Konovalenko
Y1  - 2019/08/06
PY  - 2019
N1  - https://doi.org/10.11648/j.ajbls.20190704.11
DO  - 10.11648/j.ajbls.20190704.11
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 73
EP  - 78
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20190704.11
AB  - An article deals with the influence of the transforming growth factor beta-1 (TGF-β1) on the carcinogenesis of hepatic cells, as well as attention is given to the role of this factor in the hepatocellular carcinoma (HCC) progression. We monitored two groups of patients: in the treatment group, patients were administered cancer vaccine therapy and anti-relapse immune corrector Arecur® – a complex of exogenous peptides with anti-inflammatory, anti-infective and regenerating properties; in the reference group, patients were not administered immune corrector. The study showed that the cancer vaccine has a positive effect on the activity of T-cell immunity and interleukin-2 expression level. The result of the inclusion of anti-relapse immune corrector Arecur® in the patients’ management regimen was the reduction of TGF-β1 expression. The lower recurrence rate of HCC in the treatment group suggests that Arecur® may prevent possible recurrences and metastasis of HCC by limiting TGF-β1 expression. Future researches of anti-relapse immune correction regimens for patients with hepatic tumours may improve the therapeutic strategy and prevention of the disease progression in the long term. In addition, immune correction using exogenous peptides is likely capable of preventing the malignancy in patients with chronic hepatitis and liver cirrhosis.
VL  - 7
IS  - 4
ER  -

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