Crude Extracts of <i>Mitracarpus scaber</i> Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats

Okonkwo Francis Obiora; Jonathan Bege; Ibibra Joel Agat; Nvau John Barnabas

doi:doi:10.11648/j.ajbls.20190706.14

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Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats

Okonkwo Francis Obiora, Jonathan Bege, Ibibra Joel Agat, Nvau John Barnabas

Published in American Journal of Biomedical and Life Sciences (Volume 7, Issue 6)

Received: 16 October 2019 Accepted: 8 November 2019 Published: 27 November 2019

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Abstract

Traditional medicine has received considerable acceptance in recent years, especially in Africa probably due to perceived efficacy and the fact that they are a cheap source of medicine. It can also be attributed to the pharmacological properties of plants, including antioxidant and hepatoprotective properties. The hepatoprotective effects of aqueous extract and 10% ethanolic extract of the roots of Mitracarpus scaber against paracetamol (PCM)-induced hepatotoxicity in Wistar rats of both sexes were investigated. Liver damage was induced by oral administration of 1.5mg/kg bodyweight of PCM. After pre-treatment for 6 days with aqueous and ethanolic extract of Mitracarpus scaber root (200 and 500mg/kg), hepatoprotective properties of the plant was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), followed by histopathology, as compared with the control group (group induced with liver damage but not treated). Administration of the extracts showed significant (p<0.05) and dose-dependent hepatoprotective activity resulting in decrease in the activity of ALT and AST. These data revealed that the roots of Mitracarpus scaber aqueous and ethanolic extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.

Published in	American Journal of Biomedical and Life Sciences (Volume 7, Issue 6)
DOI	10.11648/j.ajbls.20190706.14
Page(s)	148-154
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Mitracarpus scaber, Roots, Paracetamol, Hepatoprotection, Medicinal Plants

References

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APA Style

Okonkwo Francis Obiora, Jonathan Bege, Ibibra Joel Agat, Nvau John Barnabas. (2019). Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats. American Journal of Biomedical and Life Sciences, 7(6), 148-154. https://doi.org/10.11648/j.ajbls.20190706.14

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ACS Style

Okonkwo Francis Obiora; Jonathan Bege; Ibibra Joel Agat; Nvau John Barnabas. Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats. Am. J. Biomed. Life Sci. 2019, 7(6), 148-154. doi: 10.11648/j.ajbls.20190706.14

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AMA Style

Okonkwo Francis Obiora, Jonathan Bege, Ibibra Joel Agat, Nvau John Barnabas. Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats. Am J Biomed Life Sci. 2019;7(6):148-154. doi: 10.11648/j.ajbls.20190706.14

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@article{10.11648/j.ajbls.20190706.14,
  author = {Okonkwo Francis Obiora and Jonathan Bege and Ibibra Joel Agat and Nvau John Barnabas},
  title = {Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {7},
  number = {6},
  pages = {148-154},
  doi = {10.11648/j.ajbls.20190706.14},
  url = {https://doi.org/10.11648/j.ajbls.20190706.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20190706.14},
  abstract = {Traditional medicine has received considerable acceptance in recent years, especially in Africa probably due to perceived efficacy and the fact that they are a cheap source of medicine. It can also be attributed to the pharmacological properties of plants, including antioxidant and hepatoprotective properties. The hepatoprotective effects of aqueous extract and 10% ethanolic extract of the roots of Mitracarpus scaber against paracetamol (PCM)-induced hepatotoxicity in Wistar rats of both sexes were investigated. Liver damage was induced by oral administration of 1.5mg/kg bodyweight of PCM. After pre-treatment for 6 days with aqueous and ethanolic extract of Mitracarpus scaber root (200 and 500mg/kg), hepatoprotective properties of the plant was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), followed by histopathology, as compared with the control group (group induced with liver damage but not treated). Administration of the extracts showed significant (pMitracarpus scaber aqueous and ethanolic extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.},
 year = {2019}
}

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TY  - JOUR
T1  - Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats
AU  - Okonkwo Francis Obiora
AU  - Jonathan Bege
AU  - Ibibra Joel Agat
AU  - Nvau John Barnabas
Y1  - 2019/11/27
PY  - 2019
N1  - https://doi.org/10.11648/j.ajbls.20190706.14
DO  - 10.11648/j.ajbls.20190706.14
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 148
EP  - 154
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20190706.14
AB  - Traditional medicine has received considerable acceptance in recent years, especially in Africa probably due to perceived efficacy and the fact that they are a cheap source of medicine. It can also be attributed to the pharmacological properties of plants, including antioxidant and hepatoprotective properties. The hepatoprotective effects of aqueous extract and 10% ethanolic extract of the roots of Mitracarpus scaber against paracetamol (PCM)-induced hepatotoxicity in Wistar rats of both sexes were investigated. Liver damage was induced by oral administration of 1.5mg/kg bodyweight of PCM. After pre-treatment for 6 days with aqueous and ethanolic extract of Mitracarpus scaber root (200 and 500mg/kg), hepatoprotective properties of the plant was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), followed by histopathology, as compared with the control group (group induced with liver damage but not treated). Administration of the extracts showed significant (pMitracarpus scaber aqueous and ethanolic extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.
VL  - 7
IS  - 6
ER  -

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Author Information

Okonkwo Francis Obiora

Department of Biochemistry, Faculty of Natural and Applied Sciences, Plateau State University, Bokkos, Nigeria
Jonathan Bege

Department of Biochemistry, Faculty of Natural and Applied Sciences, Plateau State University, Bokkos, Nigeria
Ibibra Joel Agat

Department of Biochemistry, Faculty of Natural and Applied Sciences, Plateau State University, Bokkos, Nigeria
Nvau John Barnabas

Department of Chemistry, Faculty of Natural and Applied Scinces, Plateau State University, Bokkos, Nigeria

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APA Style

Okonkwo Francis Obiora, Jonathan Bege, Ibibra Joel Agat, Nvau John Barnabas. (2019). Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats. American Journal of Biomedical and Life Sciences, 7(6), 148-154. https://doi.org/10.11648/j.ajbls.20190706.14

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ACS Style

Okonkwo Francis Obiora; Jonathan Bege; Ibibra Joel Agat; Nvau John Barnabas. Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats. Am. J. Biomed. Life Sci. 2019, 7(6), 148-154. doi: 10.11648/j.ajbls.20190706.14

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AMA Style

Okonkwo Francis Obiora, Jonathan Bege, Ibibra Joel Agat, Nvau John Barnabas. Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats. Am J Biomed Life Sci. 2019;7(6):148-154. doi: 10.11648/j.ajbls.20190706.14

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@article{10.11648/j.ajbls.20190706.14,
  author = {Okonkwo Francis Obiora and Jonathan Bege and Ibibra Joel Agat and Nvau John Barnabas},
  title = {Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats},
  journal = {American Journal of Biomedical and Life Sciences},
  volume = {7},
  number = {6},
  pages = {148-154},
  doi = {10.11648/j.ajbls.20190706.14},
  url = {https://doi.org/10.11648/j.ajbls.20190706.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20190706.14},
  abstract = {Traditional medicine has received considerable acceptance in recent years, especially in Africa probably due to perceived efficacy and the fact that they are a cheap source of medicine. It can also be attributed to the pharmacological properties of plants, including antioxidant and hepatoprotective properties. The hepatoprotective effects of aqueous extract and 10% ethanolic extract of the roots of Mitracarpus scaber against paracetamol (PCM)-induced hepatotoxicity in Wistar rats of both sexes were investigated. Liver damage was induced by oral administration of 1.5mg/kg bodyweight of PCM. After pre-treatment for 6 days with aqueous and ethanolic extract of Mitracarpus scaber root (200 and 500mg/kg), hepatoprotective properties of the plant was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), followed by histopathology, as compared with the control group (group induced with liver damage but not treated). Administration of the extracts showed significant (pMitracarpus scaber aqueous and ethanolic extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.},
 year = {2019}
}

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TY  - JOUR
T1  - Crude Extracts of Mitracarpus scaber Roots Significantly Ameliorate Paracetamol (PCM)-Induced Liver Damage in Rats
AU  - Okonkwo Francis Obiora
AU  - Jonathan Bege
AU  - Ibibra Joel Agat
AU  - Nvau John Barnabas
Y1  - 2019/11/27
PY  - 2019
N1  - https://doi.org/10.11648/j.ajbls.20190706.14
DO  - 10.11648/j.ajbls.20190706.14
T2  - American Journal of Biomedical and Life Sciences
JF  - American Journal of Biomedical and Life Sciences
JO  - American Journal of Biomedical and Life Sciences
SP  - 148
EP  - 154
PB  - Science Publishing Group
SN  - 2330-880X
UR  - https://doi.org/10.11648/j.ajbls.20190706.14
AB  - Traditional medicine has received considerable acceptance in recent years, especially in Africa probably due to perceived efficacy and the fact that they are a cheap source of medicine. It can also be attributed to the pharmacological properties of plants, including antioxidant and hepatoprotective properties. The hepatoprotective effects of aqueous extract and 10% ethanolic extract of the roots of Mitracarpus scaber against paracetamol (PCM)-induced hepatotoxicity in Wistar rats of both sexes were investigated. Liver damage was induced by oral administration of 1.5mg/kg bodyweight of PCM. After pre-treatment for 6 days with aqueous and ethanolic extract of Mitracarpus scaber root (200 and 500mg/kg), hepatoprotective properties of the plant was evaluated by estimating the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), followed by histopathology, as compared with the control group (group induced with liver damage but not treated). Administration of the extracts showed significant (pMitracarpus scaber aqueous and ethanolic extracts possess significant hepatoprotective activity against PCM-induced toxicity attributable to its constituent phytochemicals. The mechanism of hepatoprotection seems to be through the modulation of antioxidant enzyme systems.
VL  - 7
IS  - 6
ER  -

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