Modern View on the Problem of Bronchial Asthma Comorbidity

Mykola Ostrovskyy; Lilia Todoriko; Oleksandr Varunkiv; Iryna Makoida; Halyna Korzh; Mariana Kulynych-Miskiv; Liudmyla Babliuk; Olha Molodovets

doi:doi:10.11648/j.ajim.20200802.11

Modern View on the Problem of Bronchial Asthma Comorbidity

Mykola Ostrovskyy, Lilia Todoriko, Oleksandr Varunkiv, Iryna Makoida, Halyna Korzh, Mariana Kulynych-Miskiv, Liudmyla Babliuk, Olha Molodovets

Published in American Journal of Internal Medicine (Volume 8, Issue 2)

Received: 24 December 2019 Accepted: 4 February 2020 Published: 2 March 2020

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Abstract

We have examined 40 patients with bronchial asthma (BA) based at the municipal non-profit enterprise "Ivano-Frankivsk Regional Phthisiopulmonology Center of the Ivano-Frankivsk Regional Council" (Center for Pulmonary Diseases). The patients were randomized into two groups: Group I (17) involved patients with BA, Group II included (23) patients suffering from BA with obesity. The goal of the research work was to analyze the manifestations of clinical symptomatology, manageability of BA, state of pulmonary function, level of leptin in relation to mono- or polymorbidity. The research findings show the decrease in asthma manageability level in patients with combined pathology, particularly BA + obesity + gastroesophageal reflux disease (GERD), significant negative correlation (r=-0.95, p<0.001) between FEV1 and ACQ-5 data in patients suffering from BA with obesity and GERD. The frequency of nocturnal asthma attacks, heartburn, and sleep disorders tended to increase in patients with comorbid conditions. Features of changes in the concentration of leptin depending on the detected pathology is characterized by the following data. The level of leptin in patients with BA with and without obesity is 4.82 times higher as compared to patients with combined pathology (45.28 ± 10.42 ng/ml), and is significantly different (p<0.05) from the indices observed in patients with normal body weight (9.40 ± 1.52 ng/ml).

Published in	American Journal of Internal Medicine (Volume 8, Issue 2) This article belongs to the Special Issue New Approaches to Manage Difficult-to-Control, Severe Asthma
DOI	10.11648/j.ajim.20200802.11
Page(s)	51-56
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Bronchial Asthma, Obesity, Spirometry, Polymorbidity

References

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[2]	Velichko VI, Wenger II, Platonov OM. Bronchial asthma, obesity and gastroesophageal reflux disease: possible mechanisms of correlation. Odesa Medical Journal 2013 (Ukr); 3 (137): 57-62.
[3]	Dragomiretska NV, Zabolotna IB, Guscha SG, Kalinichenko MV, Yizha GM. New possibilities of treatment of refractory gastroesophageal reflex disease. Bulletin of problems of biology and medicine 2019 (Ukr); 2 (149): 138-141.
[4]	Ostrovskyy MM. Changes to GINA 2019: new perspectives for Patient and Doctor. Asthma and Allergy 2019 (Ukr); 4: 68-59.
[5]	Suhan VS. Comorbid course of bronchial asthma and obesity. Ukraine. Nation's health 2018 (Ukr); 2 (49): 70-72.
[6]	Fediv OI, Miller OB. Hypolipidemic therapy in the complex treatment of obesity-associated bronchial asthma, taking into account gene polymorphism. Young scientist 2017 (Ukr); 9 (49): 70-74.
[7]	Feshchenko YI. Bronchial asthma, chronic obstructive pulmonary disease: a promising global strategy for management, advanced diagnostic methods, current approaches to therapy. Asthma and Allergy 2015 (Ukr); 4: 38-42.
[8]	Feshchenko YI, Ostrovskyy MM, Varunkiv OI. Treatment of bronchial obstructive syndrome: beta-agonists. Ukrainian Pulmonary Journal 2019 (Ukr); 3 (105): 32-36.
[9]	Feshchenko YI. New approaches to improving treatment of bronchial asthma in world practice. Asthma and Allergy 2019 (Ukr); 4: 56-57.
[10]	Yashina LO. Bronchial asthma is an urgent problem today. Ukrainian Pulmonary Journal 2018 (Ukr); 3: 19-23.
[11]	GINA 2018. Updated 2018. Available at: www.ginasthma.org.
[12]	Boeckxstaens G. El-Serag H. B., Smout A. Symptomatic reflux disease: the present, the past and the future. BMJ 2014; 63 (7): 1185–1193.
[13]	Boulet L. P. Asthma and obesity. Clin. Exp. Allergy 2013; 43 (1): 8-21.
[14]	Juel C. T., Ulrik C. S. Obesity and asthma: impact on severity, asthma control, and response to therapy. Respir Care 2013; 58 (5): 867-873.
[15]	Zhao X M. R. FTO and obesity: mechanisms of association. Curr Diab Rep. 2014; 14 (5): 486.

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APA Style

Mykola Ostrovskyy, Lilia Todoriko, Oleksandr Varunkiv, Iryna Makoida, Halyna Korzh, et al. (2020). Modern View on the Problem of Bronchial Asthma Comorbidity. American Journal of Internal Medicine, 8(2), 51-56. https://doi.org/10.11648/j.ajim.20200802.11

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ACS Style

Mykola Ostrovskyy; Lilia Todoriko; Oleksandr Varunkiv; Iryna Makoida; Halyna Korzh, et al. Modern View on the Problem of Bronchial Asthma Comorbidity. Am. J. Intern. Med. 2020, 8(2), 51-56. doi: 10.11648/j.ajim.20200802.11

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AMA Style

Mykola Ostrovskyy, Lilia Todoriko, Oleksandr Varunkiv, Iryna Makoida, Halyna Korzh, et al. Modern View on the Problem of Bronchial Asthma Comorbidity. Am J Intern Med. 2020;8(2):51-56. doi: 10.11648/j.ajim.20200802.11

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@article{10.11648/j.ajim.20200802.11,
  author = {Mykola Ostrovskyy and Lilia Todoriko and Oleksandr Varunkiv and Iryna Makoida and Halyna Korzh and Mariana Kulynych-Miskiv and Liudmyla Babliuk and Olha Molodovets},
  title = {Modern View on the Problem of Bronchial Asthma Comorbidity},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {2},
  pages = {51-56},
  doi = {10.11648/j.ajim.20200802.11},
  url = {https://doi.org/10.11648/j.ajim.20200802.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200802.11},
  abstract = {We have examined 40 patients with bronchial asthma (BA) based at the municipal non-profit enterprise "Ivano-Frankivsk Regional Phthisiopulmonology Center of the Ivano-Frankivsk Regional Council" (Center for Pulmonary Diseases). The patients were randomized into two groups: Group I (17) involved patients with BA, Group II included (23) patients suffering from BA with obesity. The goal of the research work was to analyze the manifestations of clinical symptomatology, manageability of BA, state of pulmonary function, level of leptin in relation to mono- or polymorbidity. The research findings show the decrease in asthma manageability level in patients with combined pathology, particularly BA + obesity + gastroesophageal reflux disease (GERD), significant negative correlation (r=-0.95, p<0.001) between FEV1 and ACQ-5 data in patients suffering from BA with obesity and GERD. The frequency of nocturnal asthma attacks, heartburn, and sleep disorders tended to increase in patients with comorbid conditions. Features of changes in the concentration of leptin depending on the detected pathology is characterized by the following data. The level of leptin in patients with BA with and without obesity is 4.82 times higher as compared to patients with combined pathology (45.28 ± 10.42 ng/ml), and is significantly different (p<0.05) from the indices observed in patients with normal body weight (9.40 ± 1.52 ng/ml).},
 year = {2020}
}

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TY  - JOUR
T1  - Modern View on the Problem of Bronchial Asthma Comorbidity
AU  - Mykola Ostrovskyy
AU  - Lilia Todoriko
AU  - Oleksandr Varunkiv
AU  - Iryna Makoida
AU  - Halyna Korzh
AU  - Mariana Kulynych-Miskiv
AU  - Liudmyla Babliuk
AU  - Olha Molodovets
Y1  - 2020/03/02
PY  - 2020
N1  - https://doi.org/10.11648/j.ajim.20200802.11
DO  - 10.11648/j.ajim.20200802.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 51
EP  - 56
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20200802.11
AB  - We have examined 40 patients with bronchial asthma (BA) based at the municipal non-profit enterprise "Ivano-Frankivsk Regional Phthisiopulmonology Center of the Ivano-Frankivsk Regional Council" (Center for Pulmonary Diseases). The patients were randomized into two groups: Group I (17) involved patients with BA, Group II included (23) patients suffering from BA with obesity. The goal of the research work was to analyze the manifestations of clinical symptomatology, manageability of BA, state of pulmonary function, level of leptin in relation to mono- or polymorbidity. The research findings show the decrease in asthma manageability level in patients with combined pathology, particularly BA + obesity + gastroesophageal reflux disease (GERD), significant negative correlation (r=-0.95, p<0.001) between FEV1 and ACQ-5 data in patients suffering from BA with obesity and GERD. The frequency of nocturnal asthma attacks, heartburn, and sleep disorders tended to increase in patients with comorbid conditions. Features of changes in the concentration of leptin depending on the detected pathology is characterized by the following data. The level of leptin in patients with BA with and without obesity is 4.82 times higher as compared to patients with combined pathology (45.28 ± 10.42 ng/ml), and is significantly different (p<0.05) from the indices observed in patients with normal body weight (9.40 ± 1.52 ng/ml).
VL  - 8
IS  - 2
ER  -

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Author Information

Mykola Ostrovskyy

Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Lilia Todoriko

Department of Phthisiology & Pulmonology, Higher State Educational Establishment “Bukovinian State Medical University”, Chernivtsi, Ukraine
Oleksandr Varunkiv

Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Iryna Makoida

Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Halyna Korzh

Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Mariana Kulynych-Miskiv

Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Liudmyla Babliuk

Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Olha Molodovets

Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine

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Plain Text BibTeX RIS

APA Style

Mykola Ostrovskyy, Lilia Todoriko, Oleksandr Varunkiv, Iryna Makoida, Halyna Korzh, et al. (2020). Modern View on the Problem of Bronchial Asthma Comorbidity. American Journal of Internal Medicine, 8(2), 51-56. https://doi.org/10.11648/j.ajim.20200802.11

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ACS Style

Mykola Ostrovskyy; Lilia Todoriko; Oleksandr Varunkiv; Iryna Makoida; Halyna Korzh, et al. Modern View on the Problem of Bronchial Asthma Comorbidity. Am. J. Intern. Med. 2020, 8(2), 51-56. doi: 10.11648/j.ajim.20200802.11

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AMA Style

Mykola Ostrovskyy, Lilia Todoriko, Oleksandr Varunkiv, Iryna Makoida, Halyna Korzh, et al. Modern View on the Problem of Bronchial Asthma Comorbidity. Am J Intern Med. 2020;8(2):51-56. doi: 10.11648/j.ajim.20200802.11

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@article{10.11648/j.ajim.20200802.11,
  author = {Mykola Ostrovskyy and Lilia Todoriko and Oleksandr Varunkiv and Iryna Makoida and Halyna Korzh and Mariana Kulynych-Miskiv and Liudmyla Babliuk and Olha Molodovets},
  title = {Modern View on the Problem of Bronchial Asthma Comorbidity},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {2},
  pages = {51-56},
  doi = {10.11648/j.ajim.20200802.11},
  url = {https://doi.org/10.11648/j.ajim.20200802.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200802.11},
  abstract = {We have examined 40 patients with bronchial asthma (BA) based at the municipal non-profit enterprise "Ivano-Frankivsk Regional Phthisiopulmonology Center of the Ivano-Frankivsk Regional Council" (Center for Pulmonary Diseases). The patients were randomized into two groups: Group I (17) involved patients with BA, Group II included (23) patients suffering from BA with obesity. The goal of the research work was to analyze the manifestations of clinical symptomatology, manageability of BA, state of pulmonary function, level of leptin in relation to mono- or polymorbidity. The research findings show the decrease in asthma manageability level in patients with combined pathology, particularly BA + obesity + gastroesophageal reflux disease (GERD), significant negative correlation (r=-0.95, p<0.001) between FEV1 and ACQ-5 data in patients suffering from BA with obesity and GERD. The frequency of nocturnal asthma attacks, heartburn, and sleep disorders tended to increase in patients with comorbid conditions. Features of changes in the concentration of leptin depending on the detected pathology is characterized by the following data. The level of leptin in patients with BA with and without obesity is 4.82 times higher as compared to patients with combined pathology (45.28 ± 10.42 ng/ml), and is significantly different (p<0.05) from the indices observed in patients with normal body weight (9.40 ± 1.52 ng/ml).},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Modern View on the Problem of Bronchial Asthma Comorbidity
AU  - Mykola Ostrovskyy
AU  - Lilia Todoriko
AU  - Oleksandr Varunkiv
AU  - Iryna Makoida
AU  - Halyna Korzh
AU  - Mariana Kulynych-Miskiv
AU  - Liudmyla Babliuk
AU  - Olha Molodovets
Y1  - 2020/03/02
PY  - 2020
N1  - https://doi.org/10.11648/j.ajim.20200802.11
DO  - 10.11648/j.ajim.20200802.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 51
EP  - 56
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20200802.11
AB  - We have examined 40 patients with bronchial asthma (BA) based at the municipal non-profit enterprise "Ivano-Frankivsk Regional Phthisiopulmonology Center of the Ivano-Frankivsk Regional Council" (Center for Pulmonary Diseases). The patients were randomized into two groups: Group I (17) involved patients with BA, Group II included (23) patients suffering from BA with obesity. The goal of the research work was to analyze the manifestations of clinical symptomatology, manageability of BA, state of pulmonary function, level of leptin in relation to mono- or polymorbidity. The research findings show the decrease in asthma manageability level in patients with combined pathology, particularly BA + obesity + gastroesophageal reflux disease (GERD), significant negative correlation (r=-0.95, p<0.001) between FEV1 and ACQ-5 data in patients suffering from BA with obesity and GERD. The frequency of nocturnal asthma attacks, heartburn, and sleep disorders tended to increase in patients with comorbid conditions. Features of changes in the concentration of leptin depending on the detected pathology is characterized by the following data. The level of leptin in patients with BA with and without obesity is 4.82 times higher as compared to patients with combined pathology (45.28 ± 10.42 ng/ml), and is significantly different (p<0.05) from the indices observed in patients with normal body weight (9.40 ± 1.52 ng/ml).
VL  - 8
IS  - 2
ER  -

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