Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment

Tetyana Konstantynovych; Anna Demchuk; Alina Dovgan; Yuriy Mostovoy

doi:doi:10.11648/j.ajim.20200802.14

| Peer-Reviewed

Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment

Tetyana Konstantynovych, Anna Demchuk, Alina Dovgan, Yuriy Mostovoy

Published in American Journal of Internal Medicine (Volume 8, Issue 2)

Received: 7 February 2020 Accepted: 27 February 2020 Published: 10 March 2020

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

The investigation is devoted to the problem of improvement of diagnostics and treatment of the somatopsychic phenotype (SPPh) at patients with bronchial asthma (BA). On the basis of complex clinical, instrumental, psychological inspection, investigation of the parameters of life quality by MOS SF-36 questionnaire of 207 BA-patients certain prevalence of the combination of concomitant psycho-emotional disorders in 39.1% of BA patients, such as high levels of anxiety, neurotism, clinically significant depressive symptoms and somatopsychological accentuations (pedantry, emotionality, anxiety, excitability, cyclothymia and dysthymia). It is established, that BA patients have the somatopsychic phenotype of the course of the disease. We described the features of clinical course of BA, lung functional parameters and indexes of quality of life at patients with the pathologically changed somatopsychological descriptions. It is associated with an increase in the clinical severity of the disease, a decrease in the lung function parameters, low quality of life indexes and absence of asthma control. Assignment of psychotropic drugs (fabomotisol dihydrochloride (afobazole) or piracetam/thiotriazoline) in the complex treatment leads to stabilization of the clinical and psychological state of patients, increasing the level of control of asthma. The clinical and economic effectiveness of using of the combined modes of therapy with including of preparations of psychotropic action on a base treatment was proved.

Published in	American Journal of Internal Medicine (Volume 8, Issue 2) This article belongs to the Special Issue New Approaches to Manage Difficult-to-Control, Severe Asthma
DOI	10.11648/j.ajim.20200802.14
Page(s)	66-72
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Bronchial Asthma, Somatopsychic Phenotype, Life Quality, Diagnostics, Treatment

References

[1]	Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. (GINA 2019) online appendix. Electronic resource: Available from: http://ginasthma.org/2019-gina-report-global-strategy-for-asthma-management-and-prevention.
[2]	Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. (GINA 2018) online appendix Electronic resource: Available from: http://ginasthma.org/2.2018-online-appendix-global-strategy-for-asthma-management-and-prevention.
[3]	Boulet P. Influence of comorbid conditions on asthma. Eur Respir Journ, 2009; 33, pp. 897-906.
[4]	Global asthma report 2018. Electronic resource: Available from: http://www.globalasthmareport.org/Global%20Asthma%20Report%202018.pdf.
[5]	Bel E. H. Clinical phenotypes of asthma. Curr. Opin. Med., 2004; 10, pp. 44-50.
[6]	Sara Agnafors, Anna Norman Kjellström, Jarl Torgerson and Marie Rusner, Somatic comorbidity in children and adolescents with psychiatric disorders, European Child & Adolescent Psychiatry, 2019. 10.1007/s00787-019-01313-9.
[7]	Thomas Mike, Bruton Anne, Moffatt Mandy, Cleland Jennifer. Asthma and psuchological dysfunction. – Primary Care Respiratory Journal, 2011, Vol. 20, № 3, рр. 250-256.
[8]	Soo Yeon Kim, Sun Ha Choi, Jong Deok Kim, In Suk Sol, Min Jung Kim, Yoon Hee Kim, Young-Chul Jung, Myung Hyun Sohn and Kyung Won Kim, Korean Youth with Comorbid Allergic Disease and Obesity Show Heightened Psychological Distress, The Journal of Pediatrics, 2018. 10.1016/j.jpeds.2018.10.037.
[9]	Retyunsky K. Yu., Petrenko T. S., Guryeva A. K. Mental disorders in bronchial asthma: scientific substantiation of the mechanisms of the initiation (science review). Psychiatry and Psychopharmacotherapy, 2018, Vol. 20, № 5, рр. 44–51.
[10]	Farzin Irani, Cognitive Functioning in Asthma: Central Nervous System and Other Influences, Handbook of Medical Neuropsychology, 2019, Vol. 10, pp. 187-200.
[11]	Gennaro Liccardi, Luigino Calzetta, Antonello Salzillo, Amedeo Piccolo, Gerardo Apicella and Paola Rogliani, Anxiety and asthma in youth. Is a stress - induced increased cholinergic tone the possible link?, Pediatric Pulmonology, 2017. Vol. 53, № 2, рр. 128-129.
[12]	Muramatsu Yoshiyuki, Muramatsu Kumiko, Mashima Ichiro, Gejyo Fumitaki. Bronchial Asthma: Psychosomatic aspect. – The Journal of the Japan Medical Association, 2001. Vol 126. 3. 375-377.
[13]	The Brussels Declaration: the need for change in asthma management / S. Holgate, H. Bisgaard, L. Bjermer, T. Hashtela et al. Europian Respiratory Journal, 2008, Vol. 32, pp. 1433-1442.
[14]	Gary James Connett, Lucy Anne Connett and Mike Thomas, Determining the reasons for poorly controlled asthma in an adolescent. BMJ, 2019. 10.1136/bmj.175, p. 175.
[15]	Ashley H. Clawson, Nicole Ruppe, Cara Nwankwo, Alexandra Blair, Marissa Baudino and Nighat Mehdi, Cognitive Behavioral Therapy for Youth with Asthma: Anxiety as an Example. Handbook of Cognitive Behavioral Therapy for Pediatric Medical Conditions, 2019. 10.1007/978-3-030-21683-2(22), pp. 345-367.
[16]	Hirokazu Kurahashi, Akihisa Okumura. Teruko Koide. Yoshihiro Ando, Hidehiko Hirata. Miyuki Magota, Kazuyoshi Watabane. Posterior reversible encephalopathy syndrome in a child with bronchial asthma. Electronic resource: Available from: https://www.sciencedirect.com/science/article/abs/pii/S038776040600057X.
[17]	Massimiliano Buoli and Alice Caldiroli, When is pharmacotherapy required for children suffering from Generalized Anxiety Disorder? Expert Opinion on Pharmacotherapy, 2019, Vol. 20, № 9, рр. 1053-1056.
[18]	Kew K. M., Nashed M., Dulay V., Yorke J. (2016) Cognitive behavioral therapy (CBT) for adults and adolescents with asthma. Cochrane Database of Systematic Reviews, issue 9: CD011818. – Electronic resource: http:www.ncbi.nlm.nih.gov/pubmed/27649894.
[19]	Asthma Control Test, Quality Metric Incorporated. Electronic resource: Available from: https://www.memphischildrens.org/Asthma_Control-12-and-older.pdf.
[20]	Miller M. R., Hankinson J., Brusasco V., Burgos F., Casaburi R. Et al. Standardisation of spirometry. – Eur. Respir. Journ., 2005, Vol. 26? pp. 319-368.
[21]	Schmieschek, H. Fragenbogen zur Ermittlung akzentuirter Personlichkeiten Psychiatr., Neurol und med. Psychol., 1970, Vol. 10, pp. 167-179.
[22]	Rean А. А. Prakticheskaya psikhodiagnostika lichnosti: [ucheb. posobie] - SPb.: S.-Peterb. universitet, 2001, 224 pp.
[23]	Afobazole [Fabomotizole], Instruction for use, contraindications, composition. – Electronic resource: https://nootropicspot.com/product/afobazole-fabomotizole/.
[24]	Thiocetam (Piracetam/Thiotriazoline) Instruction for use, contraindications, composition. - Electronic resource: https://compendium.com.ua/dec/260868/
[25]	Gromova O. A., Torshin I. Yu., Pronin A. V., Volkov A. Yu. Synergistic neurotrophic effects of piracetam and thiotriazoline. Neurologia, neiropsikhiatria, psikhosomatika=Neurology, neuropsychiatry, psychosomatics, 2016, Vol. 8, № 1б рр. 86-89.
[26]	Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36). -Electronic resource: Available from: https://www.brandeis.edu/roybal/docs/SF-36_website_PDF.pdf.
[27]	Buhl Achim, Zofel Peter. SPSS Vertion 10: Eifuhrung in die modern Datenanalyse unter Windows: 7., uberarbeitete und erweiterte Auflage. – Copyright 2000 by Pearson Education Deutschland GmbH. All rights reserved. – SPb.: OOO “DiaSoftYuP”, 2005. – 608 pр.

Cite This Article

Plain Text BibTeX RIS

APA Style

Tetyana Konstantynovych, Anna Demchuk, Alina Dovgan, Yuriy Mostovoy. (2020). Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment. American Journal of Internal Medicine, 8(2), 66-72. https://doi.org/10.11648/j.ajim.20200802.14

Copy | Download

ACS Style

Tetyana Konstantynovych; Anna Demchuk; Alina Dovgan; Yuriy Mostovoy. Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment. Am. J. Intern. Med. 2020, 8(2), 66-72. doi: 10.11648/j.ajim.20200802.14

Copy | Download

AMA Style

Tetyana Konstantynovych, Anna Demchuk, Alina Dovgan, Yuriy Mostovoy. Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment. Am J Intern Med. 2020;8(2):66-72. doi: 10.11648/j.ajim.20200802.14

Copy | Download

@article{10.11648/j.ajim.20200802.14,
  author = {Tetyana Konstantynovych and Anna Demchuk and Alina Dovgan and Yuriy Mostovoy},
  title = {Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {2},
  pages = {66-72},
  doi = {10.11648/j.ajim.20200802.14},
  url = {https://doi.org/10.11648/j.ajim.20200802.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200802.14},
  abstract = {The investigation is devoted to the problem of improvement of diagnostics and treatment of the somatopsychic phenotype (SPPh) at patients with bronchial asthma (BA). On the basis of complex clinical, instrumental, psychological inspection, investigation of the parameters of life quality by MOS SF-36 questionnaire of 207 BA-patients certain prevalence of the combination of concomitant psycho-emotional disorders in 39.1% of BA patients, such as high levels of anxiety, neurotism, clinically significant depressive symptoms and somatopsychological accentuations (pedantry, emotionality, anxiety, excitability, cyclothymia and dysthymia). It is established, that BA patients have the somatopsychic phenotype of the course of the disease. We described the features of clinical course of BA, lung functional parameters and indexes of quality of life at patients with the pathologically changed somatopsychological descriptions. It is associated with an increase in the clinical severity of the disease, a decrease in the lung function parameters, low quality of life indexes and absence of asthma control. Assignment of psychotropic drugs (fabomotisol dihydrochloride (afobazole) or piracetam/thiotriazoline) in the complex treatment leads to stabilization of the clinical and psychological state of patients, increasing the level of control of asthma. The clinical and economic effectiveness of using of the combined modes of therapy with including of preparations of psychotropic action on a base treatment was proved.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment
AU  - Tetyana Konstantynovych
AU  - Anna Demchuk
AU  - Alina Dovgan
AU  - Yuriy Mostovoy
Y1  - 2020/03/10
PY  - 2020
N1  - https://doi.org/10.11648/j.ajim.20200802.14
DO  - 10.11648/j.ajim.20200802.14
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 66
EP  - 72
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20200802.14
AB  - The investigation is devoted to the problem of improvement of diagnostics and treatment of the somatopsychic phenotype (SPPh) at patients with bronchial asthma (BA). On the basis of complex clinical, instrumental, psychological inspection, investigation of the parameters of life quality by MOS SF-36 questionnaire of 207 BA-patients certain prevalence of the combination of concomitant psycho-emotional disorders in 39.1% of BA patients, such as high levels of anxiety, neurotism, clinically significant depressive symptoms and somatopsychological accentuations (pedantry, emotionality, anxiety, excitability, cyclothymia and dysthymia). It is established, that BA patients have the somatopsychic phenotype of the course of the disease. We described the features of clinical course of BA, lung functional parameters and indexes of quality of life at patients with the pathologically changed somatopsychological descriptions. It is associated with an increase in the clinical severity of the disease, a decrease in the lung function parameters, low quality of life indexes and absence of asthma control. Assignment of psychotropic drugs (fabomotisol dihydrochloride (afobazole) or piracetam/thiotriazoline) in the complex treatment leads to stabilization of the clinical and psychological state of patients, increasing the level of control of asthma. The clinical and economic effectiveness of using of the combined modes of therapy with including of preparations of psychotropic action on a base treatment was proved.
VL  - 8
IS  - 2
ER  -

Copy | Download

Author Information

Tetyana Konstantynovych

Propedeutic Department to internal medicine, National Pirogov Memorial Medical University, Vinnytsya, Vinnytsia, Ukraine
Anna Demchuk

Propedeutic Department to internal medicine, National Pirogov Memorial Medical University, Vinnytsya, Vinnytsia, Ukraine
Alina Dovgan

Propedeutic Department to internal medicine, National Pirogov Memorial Medical University, Vinnytsya, Vinnytsia, Ukraine
Yuriy Mostovoy

Propedeutic Department to internal medicine, National Pirogov Memorial Medical University, Vinnytsya, Vinnytsia, Ukraine

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Tetyana Konstantynovych, Anna Demchuk, Alina Dovgan, Yuriy Mostovoy. (2020). Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment. American Journal of Internal Medicine, 8(2), 66-72. https://doi.org/10.11648/j.ajim.20200802.14

Copy | Download

ACS Style

Tetyana Konstantynovych; Anna Demchuk; Alina Dovgan; Yuriy Mostovoy. Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment. Am. J. Intern. Med. 2020, 8(2), 66-72. doi: 10.11648/j.ajim.20200802.14

Copy | Download

AMA Style

Tetyana Konstantynovych, Anna Demchuk, Alina Dovgan, Yuriy Mostovoy. Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment. Am J Intern Med. 2020;8(2):66-72. doi: 10.11648/j.ajim.20200802.14

Copy | Download

@article{10.11648/j.ajim.20200802.14,
  author = {Tetyana Konstantynovych and Anna Demchuk and Alina Dovgan and Yuriy Mostovoy},
  title = {Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {2},
  pages = {66-72},
  doi = {10.11648/j.ajim.20200802.14},
  url = {https://doi.org/10.11648/j.ajim.20200802.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200802.14},
  abstract = {The investigation is devoted to the problem of improvement of diagnostics and treatment of the somatopsychic phenotype (SPPh) at patients with bronchial asthma (BA). On the basis of complex clinical, instrumental, psychological inspection, investigation of the parameters of life quality by MOS SF-36 questionnaire of 207 BA-patients certain prevalence of the combination of concomitant psycho-emotional disorders in 39.1% of BA patients, such as high levels of anxiety, neurotism, clinically significant depressive symptoms and somatopsychological accentuations (pedantry, emotionality, anxiety, excitability, cyclothymia and dysthymia). It is established, that BA patients have the somatopsychic phenotype of the course of the disease. We described the features of clinical course of BA, lung functional parameters and indexes of quality of life at patients with the pathologically changed somatopsychological descriptions. It is associated with an increase in the clinical severity of the disease, a decrease in the lung function parameters, low quality of life indexes and absence of asthma control. Assignment of psychotropic drugs (fabomotisol dihydrochloride (afobazole) or piracetam/thiotriazoline) in the complex treatment leads to stabilization of the clinical and psychological state of patients, increasing the level of control of asthma. The clinical and economic effectiveness of using of the combined modes of therapy with including of preparations of psychotropic action on a base treatment was proved.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Somatopsychic Phenotype of the Bronchial Asthma: Diagnostics and Treatment
AU  - Tetyana Konstantynovych
AU  - Anna Demchuk
AU  - Alina Dovgan
AU  - Yuriy Mostovoy
Y1  - 2020/03/10
PY  - 2020
N1  - https://doi.org/10.11648/j.ajim.20200802.14
DO  - 10.11648/j.ajim.20200802.14
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 66
EP  - 72
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20200802.14
AB  - The investigation is devoted to the problem of improvement of diagnostics and treatment of the somatopsychic phenotype (SPPh) at patients with bronchial asthma (BA). On the basis of complex clinical, instrumental, psychological inspection, investigation of the parameters of life quality by MOS SF-36 questionnaire of 207 BA-patients certain prevalence of the combination of concomitant psycho-emotional disorders in 39.1% of BA patients, such as high levels of anxiety, neurotism, clinically significant depressive symptoms and somatopsychological accentuations (pedantry, emotionality, anxiety, excitability, cyclothymia and dysthymia). It is established, that BA patients have the somatopsychic phenotype of the course of the disease. We described the features of clinical course of BA, lung functional parameters and indexes of quality of life at patients with the pathologically changed somatopsychological descriptions. It is associated with an increase in the clinical severity of the disease, a decrease in the lung function parameters, low quality of life indexes and absence of asthma control. Assignment of psychotropic drugs (fabomotisol dihydrochloride (afobazole) or piracetam/thiotriazoline) in the complex treatment leads to stabilization of the clinical and psychological state of patients, increasing the level of control of asthma. The clinical and economic effectiveness of using of the combined modes of therapy with including of preparations of psychotropic action on a base treatment was proved.
VL  - 8
IS  - 2
ER  -

Copy | Download