Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy

Sophia Kahouli; Hafid Zahid; Saâd El kabbaj; Majid Benkirane; Nezha Messaoudi

doi:doi:10.11648/j.ajim.20200803.15

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Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy

Sophia Kahouli, Hafid Zahid, Saâd El kabbaj, Majid Benkirane, Nezha Messaoudi

Published in American Journal of Internal Medicine (Volume 8, Issue 3)

Received: 22 March 2020 Accepted: 6 May 2020 Published: 19 May 2020

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Abstract

Introduction: Non-Hodgkin's lymphoblastic B lymphoma with lymph node location is exceptional in children. Unlike acute lymphoblastic leukemia, which is the first cancer in children around the age of 3 with a favorable prognosis with a survival of 5 years in 90%. Observation: child, 15 years old. The hospital admission examination showed a febrile patient (40°C), bilateral cervical and inguinal polyadenopathies, the absence of hepatosplenomegaly. The hemogram at entry found bicytopenia made up of angerogenic anemia and thrombocytopenia. On the haematological level, there has been an evolution towards pancytopenia. A lymph node biopsy showed medullary infiltration with lymphoma cells of phenotype B. The karyotype found hyper diploidy with t (9.22). The patient was put on corticosteroid therapy, hyperhydration and (Allopurinol) followed by COP type chemotherapy (Cyclophosphamide, Oncovin, Prednisone) with good tolerance. A year later the patient presented with a feverish peak (40°C). Only a hematological relapse in the form of acute leukemia. Therapeutically, it was decided to re-induce the patient according to the GRAALL catch-up protocol (Idarubicin-Aracytine) and to propose it for an allograft of bone marrow, but unfortunately the patient died. Conclusion: Lymphoblastic lymphoma / Acute lymphoblastic leukemia B, associated with t (9; 22) and hyperdiploidy in children is an exceptional hemopathy and has a negative diagnosis.

Published in	American Journal of Internal Medicine (Volume 8, Issue 3)
DOI	10.11648/j.ajim.20200803.15
Page(s)	121-124
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Lymphoblastic Lymphoma, Acute Lymphoblastic Leukemia B, t (9.22), Hyperdiploidy, Child

References

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APA Style

Sophia Kahouli, Hafid Zahid, Saâd El kabbaj, Majid Benkirane, Nezha Messaoudi. (2020). Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy. American Journal of Internal Medicine, 8(3), 121-124. https://doi.org/10.11648/j.ajim.20200803.15

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ACS Style

Sophia Kahouli; Hafid Zahid; Saâd El kabbaj; Majid Benkirane; Nezha Messaoudi. Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy. Am. J. Intern. Med. 2020, 8(3), 121-124. doi: 10.11648/j.ajim.20200803.15

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AMA Style

Sophia Kahouli, Hafid Zahid, Saâd El kabbaj, Majid Benkirane, Nezha Messaoudi. Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy. Am J Intern Med. 2020;8(3):121-124. doi: 10.11648/j.ajim.20200803.15

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@article{10.11648/j.ajim.20200803.15,
  author = {Sophia Kahouli and Hafid Zahid and Saâd El kabbaj and Majid Benkirane and Nezha Messaoudi},
  title = {Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {3},
  pages = {121-124},
  doi = {10.11648/j.ajim.20200803.15},
  url = {https://doi.org/10.11648/j.ajim.20200803.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200803.15},
  abstract = {Introduction: Non-Hodgkin's lymphoblastic B lymphoma with lymph node location is exceptional in children. Unlike acute lymphoblastic leukemia, which is the first cancer in children around the age of 3 with a favorable prognosis with a survival of 5 years in 90%. Observation: child, 15 years old. The hospital admission examination showed a febrile patient (40°C), bilateral cervical and inguinal polyadenopathies, the absence of hepatosplenomegaly. The hemogram at entry found bicytopenia made up of angerogenic anemia and thrombocytopenia. On the haematological level, there has been an evolution towards pancytopenia. A lymph node biopsy showed medullary infiltration with lymphoma cells of phenotype B. The karyotype found hyper diploidy with t (9.22). The patient was put on corticosteroid therapy, hyperhydration and (Allopurinol) followed by COP type chemotherapy (Cyclophosphamide, Oncovin, Prednisone) with good tolerance. A year later the patient presented with a feverish peak (40°C). Only a hematological relapse in the form of acute leukemia. Therapeutically, it was decided to re-induce the patient according to the GRAALL catch-up protocol (Idarubicin-Aracytine) and to propose it for an allograft of bone marrow, but unfortunately the patient died. Conclusion: Lymphoblastic lymphoma / Acute lymphoblastic leukemia B, associated with t (9; 22) and hyperdiploidy in children is an exceptional hemopathy and has a negative diagnosis.},
 year = {2020}
}

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TY - JOUR
T1 - Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy
AU - Sophia Kahouli
AU - Hafid Zahid
AU - Saâd El kabbaj
AU - Majid Benkirane
AU - Nezha Messaoudi
Y1 - 2020/05/19
PY - 2020
N1 - https://doi.org/10.11648/j.ajim.20200803.15
DO - 10.11648/j.ajim.20200803.15
T2 - American Journal of Internal Medicine
JF - American Journal of Internal Medicine
JO - American Journal of Internal Medicine
SP - 121
EP - 124
PB - Science Publishing Group
SN - 2330-4324
UR - https://doi.org/10.11648/j.ajim.20200803.15
AB - Introduction: Non-Hodgkin's lymphoblastic B lymphoma with lymph node location is exceptional in children. Unlike acute lymphoblastic leukemia, which is the first cancer in children around the age of 3 with a favorable prognosis with a survival of 5 years in 90%. Observation: child, 15 years old. The hospital admission examination showed a febrile patient (40°C), bilateral cervical and inguinal polyadenopathies, the absence of hepatosplenomegaly. The hemogram at entry found bicytopenia made up of angerogenic anemia and thrombocytopenia. On the haematological level, there has been an evolution towards pancytopenia. A lymph node biopsy showed medullary infiltration with lymphoma cells of phenotype B. The karyotype found hyper diploidy with t (9.22). The patient was put on corticosteroid therapy, hyperhydration and (Allopurinol) followed by COP type chemotherapy (Cyclophosphamide, Oncovin, Prednisone) with good tolerance. A year later the patient presented with a feverish peak (40°C). Only a hematological relapse in the form of acute leukemia. Therapeutically, it was decided to re-induce the patient according to the GRAALL catch-up protocol (Idarubicin-Aracytine) and to propose it for an allograft of bone marrow, but unfortunately the patient died. Conclusion: Lymphoblastic lymphoma / Acute lymphoblastic leukemia B, associated with t (9; 22) and hyperdiploidy in children is an exceptional hemopathy and has a negative diagnosis.
VL - 8
IS - 3
ER -

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Author Information

Sophia Kahouli

Laboratory of Research and Medical Analysis of the Fraternal of the Royal Gendarmerie, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Hafid Zahid

Hematology-Immunohematology Service of the Military Instruction Hospital Mohammed V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Saâd El kabbaj
Majid Benkirane

Laboratory Center of the Military Instructional Hospital Mohammed V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Nezha Messaoudi

Hematology-Immunohematology Service of the Military Instruction Hospital Mohammed V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco

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APA Style

Sophia Kahouli, Hafid Zahid, Saâd El kabbaj, Majid Benkirane, Nezha Messaoudi. (2020). Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy. American Journal of Internal Medicine, 8(3), 121-124. https://doi.org/10.11648/j.ajim.20200803.15

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ACS Style

Sophia Kahouli; Hafid Zahid; Saâd El kabbaj; Majid Benkirane; Nezha Messaoudi. Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy. Am. J. Intern. Med. 2020, 8(3), 121-124. doi: 10.11648/j.ajim.20200803.15

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AMA Style

Sophia Kahouli, Hafid Zahid, Saâd El kabbaj, Majid Benkirane, Nezha Messaoudi. Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy. Am J Intern Med. 2020;8(3):121-124. doi: 10.11648/j.ajim.20200803.15

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@article{10.11648/j.ajim.20200803.15,
  author = {Sophia Kahouli and Hafid Zahid and Saâd El kabbaj and Majid Benkirane and Nezha Messaoudi},
  title = {Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy},
  journal = {American Journal of Internal Medicine},
  volume = {8},
  number = {3},
  pages = {121-124},
  doi = {10.11648/j.ajim.20200803.15},
  url = {https://doi.org/10.11648/j.ajim.20200803.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200803.15},
  abstract = {Introduction: Non-Hodgkin's lymphoblastic B lymphoma with lymph node location is exceptional in children. Unlike acute lymphoblastic leukemia, which is the first cancer in children around the age of 3 with a favorable prognosis with a survival of 5 years in 90%. Observation: child, 15 years old. The hospital admission examination showed a febrile patient (40°C), bilateral cervical and inguinal polyadenopathies, the absence of hepatosplenomegaly. The hemogram at entry found bicytopenia made up of angerogenic anemia and thrombocytopenia. On the haematological level, there has been an evolution towards pancytopenia. A lymph node biopsy showed medullary infiltration with lymphoma cells of phenotype B. The karyotype found hyper diploidy with t (9.22). The patient was put on corticosteroid therapy, hyperhydration and (Allopurinol) followed by COP type chemotherapy (Cyclophosphamide, Oncovin, Prednisone) with good tolerance. A year later the patient presented with a feverish peak (40°C). Only a hematological relapse in the form of acute leukemia. Therapeutically, it was decided to re-induce the patient according to the GRAALL catch-up protocol (Idarubicin-Aracytine) and to propose it for an allograft of bone marrow, but unfortunately the patient died. Conclusion: Lymphoblastic lymphoma / Acute lymphoblastic leukemia B, associated with t (9; 22) and hyperdiploidy in children is an exceptional hemopathy and has a negative diagnosis.},
 year = {2020}
}

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