Background: The SARS-CoV-2 infection has polymorphic clinical presentations. The real time PCR is the reference diagnostic test; however, it can only detect presence of virus for a specific window of time. Case: We report a clinical case in a patient aged 66 years. His clinical history included known hypertension for 10 years and ischemic stroke. He had no known contact with infected persons. He initially presented with a productive cough, fever, shortness of breath on exertion, intense asthenia and palpitations. The real time PCR with upper airway samples was conducted on days 18 and 20 of the onset of symptoms and was negative. Despite chest CT abnormalities, the patient was not considered to be infected SARS-CoV-2 according to national recommendations for diagnosis and treatment in Benin. He was discharged from the treatment centre. Readmitted 7 days later to the emergency room for respiratory distress, the patient died. Conclusion. Diagnosis of SARS-CoV-2 infection can be difficult. In the context of typical clinical presentation, chest CT features of viral pneumonia may be strongly suspicious for SARS-CoV-2 despite negative real time PCR results. In order to improve the diagnostic and therapeutic strategy for SARS-CoV-2 infection in Benin, chest CT and other diagnostic tests/ criteria should be adopted.
| Published in | American Journal of Internal Medicine (Volume 8, Issue 4) |
| DOI | 10.11648/j.ajim.20200804.12 |
| Page(s) | 148-152 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
SARS-CoV-2, Real Time PCR, False Negative, Chest CT
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APA Style
Adjagba Philippe Mahouna, Adjadohoun Sonia, Hounkponou Murielle, Sonou Arnaud, Codjo Léopold, et al. (2020). Clinical Case with Negative Polymerase Chain Reaction (PCR) and Suspicious Chest Computed Tomography (CT) Images SARS-CoV-2 Infection or Not. American Journal of Internal Medicine, 8(4), 148-152. https://doi.org/10.11648/j.ajim.20200804.12
ACS Style
Adjagba Philippe Mahouna; Adjadohoun Sonia; Hounkponou Murielle; Sonou Arnaud; Codjo Léopold, et al. Clinical Case with Negative Polymerase Chain Reaction (PCR) and Suspicious Chest Computed Tomography (CT) Images SARS-CoV-2 Infection or Not. Am. J. Intern. Med. 2020, 8(4), 148-152. doi: 10.11648/j.ajim.20200804.12
AMA Style
Adjagba Philippe Mahouna, Adjadohoun Sonia, Hounkponou Murielle, Sonou Arnaud, Codjo Léopold, et al. Clinical Case with Negative Polymerase Chain Reaction (PCR) and Suspicious Chest Computed Tomography (CT) Images SARS-CoV-2 Infection or Not. Am J Intern Med. 2020;8(4):148-152. doi: 10.11648/j.ajim.20200804.12
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Download@article{10.11648/j.ajim.20200804.12,
author = {Adjagba Philippe Mahouna and Adjadohoun Sonia and Hounkponou Murielle and Sonou Arnaud and Codjo Léopold and Soho Edson and Dahito Mickaella and Avocèvou Géraud and Djoh Ingrid and Sissinto Yolande and Yèkpè Patricia and Biaou Olivier and Houenassi Dèdonougbo Martin},
title = {Clinical Case with Negative Polymerase Chain Reaction (PCR) and Suspicious Chest Computed Tomography (CT) Images SARS-CoV-2 Infection or Not},
journal = {American Journal of Internal Medicine},
volume = {8},
number = {4},
pages = {148-152},
doi = {10.11648/j.ajim.20200804.12},
url = {https://doi.org/10.11648/j.ajim.20200804.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20200804.12},
abstract = {Background: The SARS-CoV-2 infection has polymorphic clinical presentations. The real time PCR is the reference diagnostic test; however, it can only detect presence of virus for a specific window of time. Case: We report a clinical case in a patient aged 66 years. His clinical history included known hypertension for 10 years and ischemic stroke. He had no known contact with infected persons. He initially presented with a productive cough, fever, shortness of breath on exertion, intense asthenia and palpitations. The real time PCR with upper airway samples was conducted on days 18 and 20 of the onset of symptoms and was negative. Despite chest CT abnormalities, the patient was not considered to be infected SARS-CoV-2 according to national recommendations for diagnosis and treatment in Benin. He was discharged from the treatment centre. Readmitted 7 days later to the emergency room for respiratory distress, the patient died. Conclusion. Diagnosis of SARS-CoV-2 infection can be difficult. In the context of typical clinical presentation, chest CT features of viral pneumonia may be strongly suspicious for SARS-CoV-2 despite negative real time PCR results. In order to improve the diagnostic and therapeutic strategy for SARS-CoV-2 infection in Benin, chest CT and other diagnostic tests/ criteria should be adopted.},
year = {2020}
}
TY - JOUR T1 - Clinical Case with Negative Polymerase Chain Reaction (PCR) and Suspicious Chest Computed Tomography (CT) Images SARS-CoV-2 Infection or Not AU - Adjagba Philippe Mahouna AU - Adjadohoun Sonia AU - Hounkponou Murielle AU - Sonou Arnaud AU - Codjo Léopold AU - Soho Edson AU - Dahito Mickaella AU - Avocèvou Géraud AU - Djoh Ingrid AU - Sissinto Yolande AU - Yèkpè Patricia AU - Biaou Olivier AU - Houenassi Dèdonougbo Martin Y1 - 2020/06/04 PY - 2020 N1 - https://doi.org/10.11648/j.ajim.20200804.12 DO - 10.11648/j.ajim.20200804.12 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 148 EP - 152 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20200804.12 AB - Background: The SARS-CoV-2 infection has polymorphic clinical presentations. The real time PCR is the reference diagnostic test; however, it can only detect presence of virus for a specific window of time. Case: We report a clinical case in a patient aged 66 years. His clinical history included known hypertension for 10 years and ischemic stroke. He had no known contact with infected persons. He initially presented with a productive cough, fever, shortness of breath on exertion, intense asthenia and palpitations. The real time PCR with upper airway samples was conducted on days 18 and 20 of the onset of symptoms and was negative. Despite chest CT abnormalities, the patient was not considered to be infected SARS-CoV-2 according to national recommendations for diagnosis and treatment in Benin. He was discharged from the treatment centre. Readmitted 7 days later to the emergency room for respiratory distress, the patient died. Conclusion. Diagnosis of SARS-CoV-2 infection can be difficult. In the context of typical clinical presentation, chest CT features of viral pneumonia may be strongly suspicious for SARS-CoV-2 despite negative real time PCR results. In order to improve the diagnostic and therapeutic strategy for SARS-CoV-2 infection in Benin, chest CT and other diagnostic tests/ criteria should be adopted. VL - 8 IS - 4 ER -
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