@article{10.11648/j.iji.20241201.12,
  author = {Ayub Ali and Nazrul Islam and Nazrul Islam Fakir and Ahsan Kabir and Mowmita Sharmin and Tazul Islam and Masudur Rahman and Fakrul Amin Badal and Abu Taher},
  title = {The Science Underlying the Probiotic Strain Bifidobacterium in Beneficial Effects on Immunological and Gastrointestinal Health},
  journal = {International Journal of Immunology},
  volume = {12},
  number = {1},
  pages = {10-18},
  doi = {10.11648/j.iji.20241201.12},
  url = {https://doi.org/10.11648/j.iji.20241201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20241201.12},
  abstract = {Probiotics have demonstrated a lot of promise in improving gut health in humans. Despite the encouraging data, nothing is known about the therapeutic effectiveness of many of the probiotics on the market, and it's sometimes unclear how they work. Humans have long used Bifidobacterium, a well-known, multifunctional probiotic, to treat gastrointestinal, immunological, and infectious disorders. It is also therapeutically useful. This review provides a theoretical framework for comprehending the mechanisms of action of Bifidobacterium and highlights the functional advantages from the most pertinent animal and clinical trials. The genus Bifidobacterium belongs to the Actinobacteria phylum. = Firmicutes, Bacteroidetes, and Actinobacteria constitute the most abundant phyla in the human intestinal microbiota, Firmicutes and Bacteroidetes being predominant in adults, and Actinobacteria in breast-fed infants, where bifidobacteria can reach levels higher than 90% of the total bacterial population. They are among the first microbial colonizers of the intestines of newborns, and play key roles in the development of their physiology, including maturation of the immune system and use of dietary components. Indeed, some nutrients, such as human milk oligosaccharides, are important drivers of bifidobacterial development. Some Bifidobacterium strains are considered probiotic microorganisms because of their beneficial effects, and they have been included as bioactive ingredients in functional foods, mainly dairy products, as well as in food supplements and pharma products, alone, or together with, other microbes or microbial substrates. Well-documented scientific evidence of their activities is currently available for bifidobacteria containing preparations in some intestinal and extraintestinal pathologies. In particular, it regulates luminal metabolism, maintains gut microbiota stability, and eventually promotes a precisely calibrated homeostatic equilibrium in the host-microbiome relationship. An ideal probiotic selection would benefit from clinical proof of the multifunctional activities' efficacy and mechanism of action.
},
 year = {2024}
}

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TY  - JOUR
T1  - The Science Underlying the Probiotic Strain Bifidobacterium in Beneficial Effects on Immunological and Gastrointestinal Health
AU  - Ayub Ali
AU  - Nazrul Islam
AU  - Nazrul Islam Fakir
AU  - Ahsan Kabir
AU  - Mowmita Sharmin
AU  - Tazul Islam
AU  - Masudur Rahman
AU  - Fakrul Amin Badal
AU  - Abu Taher
Y1  - 2024/02/21
PY  - 2024
N1  - https://doi.org/10.11648/j.iji.20241201.12
DO  - 10.11648/j.iji.20241201.12
T2  - International Journal of Immunology
JF  - International Journal of Immunology
JO  - International Journal of Immunology
SP  - 10
EP  - 18
PB  - Science Publishing Group
SN  - 2329-1753
UR  - https://doi.org/10.11648/j.iji.20241201.12
AB  - Probiotics have demonstrated a lot of promise in improving gut health in humans. Despite the encouraging data, nothing is known about the therapeutic effectiveness of many of the probiotics on the market, and it's sometimes unclear how they work. Humans have long used Bifidobacterium, a well-known, multifunctional probiotic, to treat gastrointestinal, immunological, and infectious disorders. It is also therapeutically useful. This review provides a theoretical framework for comprehending the mechanisms of action of Bifidobacterium and highlights the functional advantages from the most pertinent animal and clinical trials. The genus Bifidobacterium belongs to the Actinobacteria phylum. = Firmicutes, Bacteroidetes, and Actinobacteria constitute the most abundant phyla in the human intestinal microbiota, Firmicutes and Bacteroidetes being predominant in adults, and Actinobacteria in breast-fed infants, where bifidobacteria can reach levels higher than 90% of the total bacterial population. They are among the first microbial colonizers of the intestines of newborns, and play key roles in the development of their physiology, including maturation of the immune system and use of dietary components. Indeed, some nutrients, such as human milk oligosaccharides, are important drivers of bifidobacterial development. Some Bifidobacterium strains are considered probiotic microorganisms because of their beneficial effects, and they have been included as bioactive ingredients in functional foods, mainly dairy products, as well as in food supplements and pharma products, alone, or together with, other microbes or microbial substrates. Well-documented scientific evidence of their activities is currently available for bifidobacteria containing preparations in some intestinal and extraintestinal pathologies. In particular, it regulates luminal metabolism, maintains gut microbiota stability, and eventually promotes a precisely calibrated homeostatic equilibrium in the host-microbiome relationship. An ideal probiotic selection would benefit from clinical proof of the multifunctional activities' efficacy and mechanism of action.

VL  - 12
IS  - 1
ER  - 

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