Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism

Li Hongyan; Zhang Jingyu; Xu Qian; Wang Cuicui; Cao Tingting; Hou Zhenjiang

doi:doi:10.11648/j.sjph.20200806.14

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Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism

Li Hongyan, Zhang Jingyu, Xu Qian, Wang Cuicui, Cao Tingting, Hou Zhenjiang

Published in Science Journal of Public Health (Volume 8, Issue 6)

Received: 23 October 2020 Published: 27 November 2020

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Abstract

Objective: To discuss the changes of serum levels of IL-2, IL-6, IL-8 and ET in patients with hyperthyroidism, and to analyze the correlation between them and thyroid function indexes, and to find more objective indexes for the diagnosis, treatment and prevention of hyperthyroidism. Methods: 251 patients with hyperthyroidism (Study Group) and 130 healthy persons (control group) were selected. Five indexes of serum thyroid function: serum free triiodothyronine (FT3), total triiodothyronine (TT3), serum free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) were measured by electrochemiluminescence. The levels of seruminterleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8) were detected by ELISA double antibody sandwich method, and the level of endothelin (ET) was measured by enzyme linked immunosorbent assay. Results: The level of IL-2 in study group was significantly lower (P<0.05), which was negatively correlated with serum FT3, FT4, TT3 and TT4; The levels of IL-6, IL-8 and ET were significantly increased (P<0.05), and positively correlated with serum FT3, FT4, TT3 and TT4; The four indexes were not correlated with serum TSH. Conclusions: IL-2, IL-6, IL-8 and ET are involved in the occurrence and development of hyperthyroidism, and monitoring the changes of each index has certain clinical application value for the diagnosis, pathogenesis research, judgment and prognosis of hyperthyroidism.

Published in	Science Journal of Public Health (Volume 8, Issue 6)
DOI	10.11648/j.sjph.20200806.14
Page(s)	177-180
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Hyperthyroidism, IL-2, IL-6, IL-8, ET

References

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APA Style

Li Hongyan, Zhang Jingyu, Xu Qian, Wang Cuicui, Cao Tingting, et al. (2020). Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism. Science Journal of Public Health, 8(6), 177-180. https://doi.org/10.11648/j.sjph.20200806.14

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ACS Style

Li Hongyan; Zhang Jingyu; Xu Qian; Wang Cuicui; Cao Tingting, et al. Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism. Sci. J. Public Health 2020, 8(6), 177-180. doi: 10.11648/j.sjph.20200806.14

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AMA Style

Li Hongyan, Zhang Jingyu, Xu Qian, Wang Cuicui, Cao Tingting, et al. Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism. Sci J Public Health. 2020;8(6):177-180. doi: 10.11648/j.sjph.20200806.14

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@article{10.11648/j.sjph.20200806.14,
  author = {Li Hongyan and Zhang Jingyu and Xu Qian and Wang Cuicui and Cao Tingting and Hou Zhenjiang},
  title = {Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism},
  journal = {Science Journal of Public Health},
  volume = {8},
  number = {6},
  pages = {177-180},
  doi = {10.11648/j.sjph.20200806.14},
  url = {https://doi.org/10.11648/j.sjph.20200806.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20200806.14},
  abstract = {Objective: To discuss the changes of serum levels of IL-2, IL-6, IL-8 and ET in patients with hyperthyroidism, and to analyze the correlation between them and thyroid function indexes, and to find more objective indexes for the diagnosis, treatment and prevention of hyperthyroidism. Methods: 251 patients with hyperthyroidism (Study Group) and 130 healthy persons (control group) were selected. Five indexes of serum thyroid function: serum free triiodothyronine (FT3), total triiodothyronine (TT3), serum free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) were measured by electrochemiluminescence. The levels of seruminterleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8) were detected by ELISA double antibody sandwich method, and the level of endothelin (ET) was measured by enzyme linked immunosorbent assay. Results: The level of IL-2 in study group was significantly lower (P<0.05), which was negatively correlated with serum FT3, FT4, TT3 and TT4; The levels of IL-6, IL-8 and ET were significantly increased (P<0.05), and positively correlated with serum FT3, FT4, TT3 and TT4; The four indexes were not correlated with serum TSH. Conclusions: IL-2, IL-6, IL-8 and ET are involved in the occurrence and development of hyperthyroidism, and monitoring the changes of each index has certain clinical application value for the diagnosis, pathogenesis research, judgment and prognosis of hyperthyroidism.},
 year = {2020}
}

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TY  - JOUR
T1  - Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism
AU  - Li Hongyan
AU  - Zhang Jingyu
AU  - Xu Qian
AU  - Wang Cuicui
AU  - Cao Tingting
AU  - Hou Zhenjiang
Y1  - 2020/11/27
PY  - 2020
N1  - https://doi.org/10.11648/j.sjph.20200806.14
DO  - 10.11648/j.sjph.20200806.14
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 177
EP  - 180
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20200806.14
AB  - Objective: To discuss the changes of serum levels of IL-2, IL-6, IL-8 and ET in patients with hyperthyroidism, and to analyze the correlation between them and thyroid function indexes, and to find more objective indexes for the diagnosis, treatment and prevention of hyperthyroidism. Methods: 251 patients with hyperthyroidism (Study Group) and 130 healthy persons (control group) were selected. Five indexes of serum thyroid function: serum free triiodothyronine (FT3), total triiodothyronine (TT3), serum free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) were measured by electrochemiluminescence. The levels of seruminterleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8) were detected by ELISA double antibody sandwich method, and the level of endothelin (ET) was measured by enzyme linked immunosorbent assay. Results: The level of IL-2 in study group was significantly lower (P<0.05), which was negatively correlated with serum FT3, FT4, TT3 and TT4; The levels of IL-6, IL-8 and ET were significantly increased (P<0.05), and positively correlated with serum FT3, FT4, TT3 and TT4; The four indexes were not correlated with serum TSH. Conclusions: IL-2, IL-6, IL-8 and ET are involved in the occurrence and development of hyperthyroidism, and monitoring the changes of each index has certain clinical application value for the diagnosis, pathogenesis research, judgment and prognosis of hyperthyroidism.
VL  - 8
IS  - 6
ER  -

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Author Information

Li Hongyan

Department of Medical Technology of Cangzhou Medical College, Cangzhou, China
Zhang Jingyu

Department of Laboratory Diagnosis, Cangzhou Integrated of Traditional Chinese and Western Medicine Hospital of Hebei Province, Cangzhou, China
Xu Qian

Department of Medical Technology of Cangzhou Medical College, Cangzhou, China
Wang Cuicui

Department of Medical Technology of Cangzhou Medical College, Cangzhou, China
Cao Tingting

Department of Medical Technology of Cangzhou Medical College, Cangzhou, China
Hou Zhenjiang

Cangzhou Thyroid Disease Engineering Research Center, Cangzhou, China

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APA Style

Li Hongyan, Zhang Jingyu, Xu Qian, Wang Cuicui, Cao Tingting, et al. (2020). Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism. Science Journal of Public Health, 8(6), 177-180. https://doi.org/10.11648/j.sjph.20200806.14

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ACS Style

Li Hongyan; Zhang Jingyu; Xu Qian; Wang Cuicui; Cao Tingting, et al. Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism. Sci. J. Public Health 2020, 8(6), 177-180. doi: 10.11648/j.sjph.20200806.14

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AMA Style

Li Hongyan, Zhang Jingyu, Xu Qian, Wang Cuicui, Cao Tingting, et al. Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism. Sci J Public Health. 2020;8(6):177-180. doi: 10.11648/j.sjph.20200806.14

Copy | Download

@article{10.11648/j.sjph.20200806.14,
  author = {Li Hongyan and Zhang Jingyu and Xu Qian and Wang Cuicui and Cao Tingting and Hou Zhenjiang},
  title = {Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism},
  journal = {Science Journal of Public Health},
  volume = {8},
  number = {6},
  pages = {177-180},
  doi = {10.11648/j.sjph.20200806.14},
  url = {https://doi.org/10.11648/j.sjph.20200806.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20200806.14},
  abstract = {Objective: To discuss the changes of serum levels of IL-2, IL-6, IL-8 and ET in patients with hyperthyroidism, and to analyze the correlation between them and thyroid function indexes, and to find more objective indexes for the diagnosis, treatment and prevention of hyperthyroidism. Methods: 251 patients with hyperthyroidism (Study Group) and 130 healthy persons (control group) were selected. Five indexes of serum thyroid function: serum free triiodothyronine (FT3), total triiodothyronine (TT3), serum free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) were measured by electrochemiluminescence. The levels of seruminterleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8) were detected by ELISA double antibody sandwich method, and the level of endothelin (ET) was measured by enzyme linked immunosorbent assay. Results: The level of IL-2 in study group was significantly lower (P<0.05), which was negatively correlated with serum FT3, FT4, TT3 and TT4; The levels of IL-6, IL-8 and ET were significantly increased (P<0.05), and positively correlated with serum FT3, FT4, TT3 and TT4; The four indexes were not correlated with serum TSH. Conclusions: IL-2, IL-6, IL-8 and ET are involved in the occurrence and development of hyperthyroidism, and monitoring the changes of each index has certain clinical application value for the diagnosis, pathogenesis research, judgment and prognosis of hyperthyroidism.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Detection and Related Research of Serum Levels of IL-2, IL-6, IL-8 and ET in Patients with Hyperthyroidism
AU  - Li Hongyan
AU  - Zhang Jingyu
AU  - Xu Qian
AU  - Wang Cuicui
AU  - Cao Tingting
AU  - Hou Zhenjiang
Y1  - 2020/11/27
PY  - 2020
N1  - https://doi.org/10.11648/j.sjph.20200806.14
DO  - 10.11648/j.sjph.20200806.14
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 177
EP  - 180
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20200806.14
AB  - Objective: To discuss the changes of serum levels of IL-2, IL-6, IL-8 and ET in patients with hyperthyroidism, and to analyze the correlation between them and thyroid function indexes, and to find more objective indexes for the diagnosis, treatment and prevention of hyperthyroidism. Methods: 251 patients with hyperthyroidism (Study Group) and 130 healthy persons (control group) were selected. Five indexes of serum thyroid function: serum free triiodothyronine (FT3), total triiodothyronine (TT3), serum free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) were measured by electrochemiluminescence. The levels of seruminterleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8) were detected by ELISA double antibody sandwich method, and the level of endothelin (ET) was measured by enzyme linked immunosorbent assay. Results: The level of IL-2 in study group was significantly lower (P<0.05), which was negatively correlated with serum FT3, FT4, TT3 and TT4; The levels of IL-6, IL-8 and ET were significantly increased (P<0.05), and positively correlated with serum FT3, FT4, TT3 and TT4; The four indexes were not correlated with serum TSH. Conclusions: IL-2, IL-6, IL-8 and ET are involved in the occurrence and development of hyperthyroidism, and monitoring the changes of each index has certain clinical application value for the diagnosis, pathogenesis research, judgment and prognosis of hyperthyroidism.
VL  - 8
IS  - 6
ER  -

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