Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study

Djibo Sayo Adamou; Aguemon Badirou; Damien Barikissou Georgia; Alkassoum Ibrahim; Mamoudou Djafar; Moumouni Garba; Tokpanoude Ignace; Aboubacar Samaïla

doi:doi:10.11648/j.wjph.20220702.12

Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study

Djibo Sayo Adamou, Aguemon Badirou, Damien Barikissou Georgia, Alkassoum Ibrahim, Mamoudou Djafar, Moumouni Garba, Tokpanoude Ignace, Aboubacar Samaïla

Published in World Journal of Public Health (Volume 7, Issue 2)

Received: 6 March 2022 Accepted: 29 March 2022 Published: 14 April 2022

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Abstract

Severe malaria is a global public health problem and remains a major cause of death among children in sub-Saharan Africa. The aim of the study is to investigate the factors associated with severe malaria mortality in children aged 0-59 months. A cross-sectional study was conducted among children aged 0-59 months admitted for severe malaria to the paediatric service of the national hospital of Niamey. This study concerned the records of children hospitalised from 1st January 2016 to 31st December 2020. The selection was made by non-probability sampling for convenience. A total of 3300 cases were selected on the basis of the selection criteria, of which 131 deaths were recorded, i.e. a case-fatality rate of 4%. The frequency of hospitalisation for severe malaria was 24.84% The factors associated with death were patient age over 48 months (OR=8.14 p=0.034), lethargy (OR=7.34 p=0.012), convulsion (OR=3.26, p=0,032), maternal age over 30 years (OR=1.61, p=0.014), not fully vaccinated (OR=1.99, p=0.021), severe pallor (OR=1.82, p=0.002), hyperglycaemia over 7 mmol (OR=6.87 p< 0.0001), severe malaria anaemia (OR=2.79 p<0,0001). Other clinical manifestations were significantly associated with death: respiratory distress (p<0.0001), altered general condition (p<0.0001), coma (p<0.0001) frequency of seizures ≥ 3 (p<0.0001), coma (p<0.0001), malnutrition (p<0.0001), dehydration (p<0.0001), hyperthermia ≥ 39°C (p<0.0001), hyperparasitemia ≥1000 p/ul (p<0.0001) and hyperleukocytosis >12000/mm3 (p<0.0001). Severe malaria remains the leading cause of hospitalisation in paediatric wards with a frequency of 24.84%. The fatality (lethality) rate was 4.00%. The factors associated with death thus defined (age over 48 months, convulsion, lethargy), a reinforcement of the technical platform as well as a good malaria prevention policy (use of impregnated mosquito nets, chemoprevention, hygiene rules, etc.) is necessary for a reduction intra-hospital mortality of this pathology.

Published in	World Journal of Public Health (Volume 7, Issue 2)
DOI	10.11648/j.wjph.20220702.12
Page(s)	46-55
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Severe Malaria, Children, Associated Factors, Niamey

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Djibo Sayo Adamou, Aguemon Badirou, Damien Barikissou Georgia, Alkassoum Ibrahim, Mamoudou Djafar, et al. (2022). Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study. World Journal of Public Health, 7(2), 46-55. https://doi.org/10.11648/j.wjph.20220702.12

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Djibo Sayo Adamou; Aguemon Badirou; Damien Barikissou Georgia; Alkassoum Ibrahim; Mamoudou Djafar, et al. Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study. World J. Public Health 2022, 7(2), 46-55. doi: 10.11648/j.wjph.20220702.12

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Djibo Sayo Adamou, Aguemon Badirou, Damien Barikissou Georgia, Alkassoum Ibrahim, Mamoudou Djafar, et al. Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study. World J Public Health. 2022;7(2):46-55. doi: 10.11648/j.wjph.20220702.12

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@article{10.11648/j.wjph.20220702.12,
  author = {Djibo Sayo Adamou and Aguemon Badirou and Damien Barikissou Georgia and Alkassoum Ibrahim and Mamoudou Djafar and Moumouni Garba and Tokpanoude Ignace and Aboubacar Samaïla},
  title = {Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study},
  journal = {World Journal of Public Health},
  volume = {7},
  number = {2},
  pages = {46-55},
  doi = {10.11648/j.wjph.20220702.12},
  url = {https://doi.org/10.11648/j.wjph.20220702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20220702.12},
  abstract = {Severe malaria is a global public health problem and remains a major cause of death among children in sub-Saharan Africa. The aim of the study is to investigate the factors associated with severe malaria mortality in children aged 0-59 months. A cross-sectional study was conducted among children aged 0-59 months admitted for severe malaria to the paediatric service of the national hospital of Niamey. This study concerned the records of children hospitalised from 1st January 2016 to 31st December 2020. The selection was made by non-probability sampling for convenience. A total of 3300 cases were selected on the basis of the selection criteria, of which 131 deaths were recorded, i.e. a case-fatality rate of 4%. The frequency of hospitalisation for severe malaria was 24.84% The factors associated with death were patient age over 48 months (OR=8.14 p=0.034), lethargy (OR=7.34 p=0.012), convulsion (OR=3.26, p=0,032), maternal age over 30 years (OR=1.61, p=0.014), not fully vaccinated (OR=1.99, p=0.021), severe pallor (OR=1.82, p=0.002), hyperglycaemia over 7 mmol (OR=6.87 p12000/mm3 (p<0.0001). Severe malaria remains the leading cause of hospitalisation in paediatric wards with a frequency of 24.84%. The fatality (lethality) rate was 4.00%. The factors associated with death thus defined (age over 48 months, convulsion, lethargy), a reinforcement of the technical platform as well as a good malaria prevention policy (use of impregnated mosquito nets, chemoprevention, hygiene rules, etc.) is necessary for a reduction intra-hospital mortality of this pathology.},
 year = {2022}
}

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TY  - JOUR
T1  - Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study
AU  - Djibo Sayo Adamou
AU  - Aguemon Badirou
AU  - Damien Barikissou Georgia
AU  - Alkassoum Ibrahim
AU  - Mamoudou Djafar
AU  - Moumouni Garba
AU  - Tokpanoude Ignace
AU  - Aboubacar Samaïla
Y1  - 2022/04/14
PY  - 2022
N1  - https://doi.org/10.11648/j.wjph.20220702.12
DO  - 10.11648/j.wjph.20220702.12
T2  - World Journal of Public Health
JF  - World Journal of Public Health
JO  - World Journal of Public Health
SP  - 46
EP  - 55
PB  - Science Publishing Group
SN  - 2637-6059
UR  - https://doi.org/10.11648/j.wjph.20220702.12
AB  - Severe malaria is a global public health problem and remains a major cause of death among children in sub-Saharan Africa. The aim of the study is to investigate the factors associated with severe malaria mortality in children aged 0-59 months. A cross-sectional study was conducted among children aged 0-59 months admitted for severe malaria to the paediatric service of the national hospital of Niamey. This study concerned the records of children hospitalised from 1st January 2016 to 31st December 2020. The selection was made by non-probability sampling for convenience. A total of 3300 cases were selected on the basis of the selection criteria, of which 131 deaths were recorded, i.e. a case-fatality rate of 4%. The frequency of hospitalisation for severe malaria was 24.84% The factors associated with death were patient age over 48 months (OR=8.14 p=0.034), lethargy (OR=7.34 p=0.012), convulsion (OR=3.26, p=0,032), maternal age over 30 years (OR=1.61, p=0.014), not fully vaccinated (OR=1.99, p=0.021), severe pallor (OR=1.82, p=0.002), hyperglycaemia over 7 mmol (OR=6.87 p12000/mm3 (p<0.0001). Severe malaria remains the leading cause of hospitalisation in paediatric wards with a frequency of 24.84%. The fatality (lethality) rate was 4.00%. The factors associated with death thus defined (age over 48 months, convulsion, lethargy), a reinforcement of the technical platform as well as a good malaria prevention policy (use of impregnated mosquito nets, chemoprevention, hygiene rules, etc.) is necessary for a reduction intra-hospital mortality of this pathology.
VL  - 7
IS  - 2
ER  -

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Author Information

Djibo Sayo Adamou

Pubic Health Unit, Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin
Aguemon Badirou

Pubic Health Unit, Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin
Damien Barikissou Georgia

Population Training and Research Centre, University of Abomey-Calavi, Cotonou, Benin
Alkassoum Ibrahim

Department of Public Health, Faculty of Health Sciences, Abdou Moumouni University, Niamey, Niger
Mamoudou Djafar

Department of Paediatrics, National Hospital, Niamey, Niger
Moumouni Garba

Department of Paediatrics, Amirou Boubacar Diallo National Hospital, Niamey, Niger
Tokpanoude Ignace

Pubic Health Unit, Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin
Aboubacar Samaïla

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APA Style

Djibo Sayo Adamou, Aguemon Badirou, Damien Barikissou Georgia, Alkassoum Ibrahim, Mamoudou Djafar, et al. (2022). Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study. World Journal of Public Health, 7(2), 46-55. https://doi.org/10.11648/j.wjph.20220702.12

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ACS Style

Djibo Sayo Adamou; Aguemon Badirou; Damien Barikissou Georgia; Alkassoum Ibrahim; Mamoudou Djafar, et al. Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study. World J. Public Health 2022, 7(2), 46-55. doi: 10.11648/j.wjph.20220702.12

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AMA Style

Djibo Sayo Adamou, Aguemon Badirou, Damien Barikissou Georgia, Alkassoum Ibrahim, Mamoudou Djafar, et al. Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study. World J Public Health. 2022;7(2):46-55. doi: 10.11648/j.wjph.20220702.12

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@article{10.11648/j.wjph.20220702.12,
  author = {Djibo Sayo Adamou and Aguemon Badirou and Damien Barikissou Georgia and Alkassoum Ibrahim and Mamoudou Djafar and Moumouni Garba and Tokpanoude Ignace and Aboubacar Samaïla},
  title = {Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study},
  journal = {World Journal of Public Health},
  volume = {7},
  number = {2},
  pages = {46-55},
  doi = {10.11648/j.wjph.20220702.12},
  url = {https://doi.org/10.11648/j.wjph.20220702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20220702.12},
  abstract = {Severe malaria is a global public health problem and remains a major cause of death among children in sub-Saharan Africa. The aim of the study is to investigate the factors associated with severe malaria mortality in children aged 0-59 months. A cross-sectional study was conducted among children aged 0-59 months admitted for severe malaria to the paediatric service of the national hospital of Niamey. This study concerned the records of children hospitalised from 1st January 2016 to 31st December 2020. The selection was made by non-probability sampling for convenience. A total of 3300 cases were selected on the basis of the selection criteria, of which 131 deaths were recorded, i.e. a case-fatality rate of 4%. The frequency of hospitalisation for severe malaria was 24.84% The factors associated with death were patient age over 48 months (OR=8.14 p=0.034), lethargy (OR=7.34 p=0.012), convulsion (OR=3.26, p=0,032), maternal age over 30 years (OR=1.61, p=0.014), not fully vaccinated (OR=1.99, p=0.021), severe pallor (OR=1.82, p=0.002), hyperglycaemia over 7 mmol (OR=6.87 p12000/mm3 (p<0.0001). Severe malaria remains the leading cause of hospitalisation in paediatric wards with a frequency of 24.84%. The fatality (lethality) rate was 4.00%. The factors associated with death thus defined (age over 48 months, convulsion, lethargy), a reinforcement of the technical platform as well as a good malaria prevention policy (use of impregnated mosquito nets, chemoprevention, hygiene rules, etc.) is necessary for a reduction intra-hospital mortality of this pathology.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Factors Associated with in-Hospital Mortality Related to Severe Malaria in Children Aged 0-59 Months at the National Hospital of Niamey: A Retrospective Study
AU  - Djibo Sayo Adamou
AU  - Aguemon Badirou
AU  - Damien Barikissou Georgia
AU  - Alkassoum Ibrahim
AU  - Mamoudou Djafar
AU  - Moumouni Garba
AU  - Tokpanoude Ignace
AU  - Aboubacar Samaïla
Y1  - 2022/04/14
PY  - 2022
N1  - https://doi.org/10.11648/j.wjph.20220702.12
DO  - 10.11648/j.wjph.20220702.12
T2  - World Journal of Public Health
JF  - World Journal of Public Health
JO  - World Journal of Public Health
SP  - 46
EP  - 55
PB  - Science Publishing Group
SN  - 2637-6059
UR  - https://doi.org/10.11648/j.wjph.20220702.12
AB  - Severe malaria is a global public health problem and remains a major cause of death among children in sub-Saharan Africa. The aim of the study is to investigate the factors associated with severe malaria mortality in children aged 0-59 months. A cross-sectional study was conducted among children aged 0-59 months admitted for severe malaria to the paediatric service of the national hospital of Niamey. This study concerned the records of children hospitalised from 1st January 2016 to 31st December 2020. The selection was made by non-probability sampling for convenience. A total of 3300 cases were selected on the basis of the selection criteria, of which 131 deaths were recorded, i.e. a case-fatality rate of 4%. The frequency of hospitalisation for severe malaria was 24.84% The factors associated with death were patient age over 48 months (OR=8.14 p=0.034), lethargy (OR=7.34 p=0.012), convulsion (OR=3.26, p=0,032), maternal age over 30 years (OR=1.61, p=0.014), not fully vaccinated (OR=1.99, p=0.021), severe pallor (OR=1.82, p=0.002), hyperglycaemia over 7 mmol (OR=6.87 p12000/mm3 (p<0.0001). Severe malaria remains the leading cause of hospitalisation in paediatric wards with a frequency of 24.84%. The fatality (lethality) rate was 4.00%. The factors associated with death thus defined (age over 48 months, convulsion, lethargy), a reinforcement of the technical platform as well as a good malaria prevention policy (use of impregnated mosquito nets, chemoprevention, hygiene rules, etc.) is necessary for a reduction intra-hospital mortality of this pathology.
VL  - 7
IS  - 2
ER  -

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