Multidrug-resistant tuberculosis (MDR-TB) is a major threat to tuberculosis (TB) control, and a common occurrence among HIV-infected patients in Nigeria. MDR-TB represents TB simultaneously resistant to at least rifampicin and isoniazid. This study aimed to identify the risk factors for MDR-TB among HIV-infected patients from four Northwestern Nigeria states attending treatment in Aminu Kano Teaching Hospital. A hospital-based retrospective case-control study was conducted by reviewing the clinical records of HIV-infected patients tested for MDR-TB from January 2015 to January 2017. A total of 111 MDR-TB cases were obtained, with equal number (111) of randomly selected controls for this study. We used a descriptive statistical technique to obtain summary values for cases and controls. Variables that showed significant association in bivariate analysis were subjected to multivariable logistic analysis. The independent predictors for MDR-TB were Female Sex (AOR=48.26, 95%, Cl: 6.39-365.88), Rural Residence (AOR=4.09, 95%, Cl: 2.05-8.17) and Age (26-45 years) (AOR=1.34, 95%, Cl: 0.56-3.59). Factors such as; Currently Married, Not Currently Married, Previously Treated and Previously Untreated showed no statistical significance at p>0.05. This study identified Female Sex, Rural Residence, and Age (26-45 years) as risk factors for MDR-TB among HIV-infected patients in Northwestern Nigeria. We recommend a prospective study for further understanding of the clinical outcomes of TB treatment and disease.
| Published in | World Journal of Public Health (Volume 7, Issue 3) |
| DOI | 10.11648/j.wjph.20220703.14 |
| Page(s) | 119-123 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Multidrug-Resistant Tuberculosis (MDR-TB), HIV, Risk Factor, Nigeria
| [1] | Sulehri, S. A. (2022). Study on the Bio-physiological and biochemical Assessment of Tuberculosis Patients using Anti TB Drugs in Baluchistan. Pak-Euro Journal of Medical and Life Sciences, 5 (2), 497-500. |
| [2] | Mathias, T., Bright Laban, W., & Patrick, O. (2022). Factors Associated with Treatment Adherence of Patients on Anti-Tuberculosis Drugs Following Covid-19 Pandemic at Health Facilities of Masaka City, Uganda. |
| [3] | Molla, K. A., Reta, M. A., & Ayene, Y. Y. (2022). Prevalence of multidrug-resistant tuberculosis in East Africa: A systematic review and meta-analysis. Plos one, 17 (6), e0270272. |
| [4] | Muntean, A. C. (2022). Case Report: Pulmonary Tuberculosis Reactivation in Patients with Human Im-munodeficiency Virus: A Case Report. Ann Clin Med Case Rep, 9 (7), 1-3. |
| [5] | Wallis, R. S., O’Garra, A., Sher, A., & Wack, A. (2022). Host-directed immunotherapy of viral and bacterial infections: past, present and future. Nature Reviews Immunology, 1-13. |
| [6] | Seo, H., Kim, S., Mahmud, H. A., Islam, M. I., Yoon, Y., Cho, H. D. & Song, H. Y. (2022). A novel class of antimicrobial drugs selectively targets a Mycobacterium tuberculosis PE-PGRS protein. PLoS Biology, 20 (5), e3001648. |
| [7] | Xi, Y., Zhang, W., Qiao, R. J., & Tang, J. (2022). Risk factors for multidrug-resistant tuberculosis: A worldwide systematic review and meta-analysis. PloS one, 17 (6), e0270003. |
| [8] | Salami, A. K., & Oluboyo, P. O. (2003). Management outcome of pulmonary tuberculosis: a nine-year review in Ilorin. West African journal of medicine, 22 (2), 114-119. |
| [9] | Otokunefor, K., Otokunefor, T. V., & Omakwele, G. (2018). Multi-drug resistant Mycobacterium tuberculosis in port harcourt, Nigeria. African Journal of Laboratory Medicine, 7 (2), 1-4. |
| [10] | George, O. T., & Oduyebo, O. O. (2022). Detection of multi-drug resistant tuberculosis (MDR TB) using microscopic observation drug susceptibility (MODS) assay in Lagos State, southwest Nigeria. African Journal of Clinical and Experimental Microbiology, 23 (2), 174-181. |
| [11] | Sebastião, C. S., Samulengo, J., Sacomboio, E., Francisco, N. M., Teixeira, C., António, S.,... & Morais, J. (2022). Epidemiological Characteristics and Risk Factors Related to Drug-resistant Tuberculosis in Luanda, Angola. The American Journal of Tropical Medicine and Hygiene, 1 (aop). |
| [12] | Fikre, A., Tewelde, T., & Shaweno, T. (2019). Determinants of multi-drug resistant tuberculosis among tuberculosis patients in Southern Ethiopia: a case control study. Journal of Medical Bacteriology, 8 (1-2), 1-12. |
| [13] | Mulu, W., Mekkonnen, D., Yimer, M., Admassu, A., & Abera, B. (2015). Risk factors for multidrug resistant tuberculosis patients in Amhara National Regional State. African health sciences, 15 (2), 368-377. |
| [14] | Workicho, A., Kassahun, W., & Alemseged, F. (2017). Risk factors for multidrug-resistant tuberculosis among tuberculosis patients: a case-control study. Infection and drug resistance, 10, 91. |
| [15] | Baya, B., Achenbach, C. J., Kone, B., Toloba, Y., Dabitao, D. K., Diarra, B. & Diallo, S. (2019). Clinical risk factors associated with multidrug-resistant tuberculosis (MDR-TB) in Mali. International Journal of Infectious Diseases, 81, 149-155. |
| [16] | Suchindran, S., Brouwer, E. S., & Van Rie, A. (2009). Is HIV infection a risk factor for multi-drug resistant tuberculosis? A systematic review. PloS one, 4 (5), e5561. |
| [17] | Tenzin, C., Chansatitporn, N., Dendup, T., Dorji, T., Lhazeen, K., Tshering, D., & Pelzang, T. (2020). Factors associated with multidrug-resistant tuberculosis (MDR-TB) in Bhutan: A nationwide case-control study. Plos one, 15 (7), e0236250. |
| [18] | World Health Organization. (2016). Consolidated guidelines on HIV prevention, diagnosis, treatment and care for key populations. |
| [19] | Lomtadze, N., Aspindzelashvili, R., Janjgava, M., Mirtskhulava, V., Wright, A., Blumberg, H. M., & Salakaia, A. (2009). Prevalence and risk factors for multidrug-resistant tuberculosis in the Republic of Georgia: a population-based study. The International journal of tuberculosis and lung disease, 13 (1), 68-73. |
| [20] | Mulisa, G., Workneh, T., Hordofa, N., Suaudi, M., Abebe, G., Jarso, G. (2015). Multidrug-resistant Mycobacterium tuberculosis and associated risk factors in Oromia Region of Ethiopia. Int. J. Infect. Dis. 39, 57–61. |
APA Style
Egbenoma Andrew Aigboeghian, Simon Ikechukwu Enem, Preciousgift Orhue Isibor. (2022). Risk Factors for Multidrug-Resistant Tuberculosis (MDR-TB) Among Human Immunodeficiency Virus (HIV)-Infected Patients in Northwestern Nigeria. World Journal of Public Health, 7(3), 119-123. https://doi.org/10.11648/j.wjph.20220703.14
ACS Style
Egbenoma Andrew Aigboeghian; Simon Ikechukwu Enem; Preciousgift Orhue Isibor. Risk Factors for Multidrug-Resistant Tuberculosis (MDR-TB) Among Human Immunodeficiency Virus (HIV)-Infected Patients in Northwestern Nigeria. World J. Public Health 2022, 7(3), 119-123. doi: 10.11648/j.wjph.20220703.14
AMA Style
Egbenoma Andrew Aigboeghian, Simon Ikechukwu Enem, Preciousgift Orhue Isibor. Risk Factors for Multidrug-Resistant Tuberculosis (MDR-TB) Among Human Immunodeficiency Virus (HIV)-Infected Patients in Northwestern Nigeria. World J Public Health. 2022;7(3):119-123. doi: 10.11648/j.wjph.20220703.14
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Download@article{10.11648/j.wjph.20220703.14,
author = {Egbenoma Andrew Aigboeghian and Simon Ikechukwu Enem and Preciousgift Orhue Isibor},
title = {Risk Factors for Multidrug-Resistant Tuberculosis (MDR-TB) Among Human Immunodeficiency Virus (HIV)-Infected Patients in Northwestern Nigeria},
journal = {World Journal of Public Health},
volume = {7},
number = {3},
pages = {119-123},
doi = {10.11648/j.wjph.20220703.14},
url = {https://doi.org/10.11648/j.wjph.20220703.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20220703.14},
abstract = {Multidrug-resistant tuberculosis (MDR-TB) is a major threat to tuberculosis (TB) control, and a common occurrence among HIV-infected patients in Nigeria. MDR-TB represents TB simultaneously resistant to at least rifampicin and isoniazid. This study aimed to identify the risk factors for MDR-TB among HIV-infected patients from four Northwestern Nigeria states attending treatment in Aminu Kano Teaching Hospital. A hospital-based retrospective case-control study was conducted by reviewing the clinical records of HIV-infected patients tested for MDR-TB from January 2015 to January 2017. A total of 111 MDR-TB cases were obtained, with equal number (111) of randomly selected controls for this study. We used a descriptive statistical technique to obtain summary values for cases and controls. Variables that showed significant association in bivariate analysis were subjected to multivariable logistic analysis. The independent predictors for MDR-TB were Female Sex (AOR=48.26, 95%, Cl: 6.39-365.88), Rural Residence (AOR=4.09, 95%, Cl: 2.05-8.17) and Age (26-45 years) (AOR=1.34, 95%, Cl: 0.56-3.59). Factors such as; Currently Married, Not Currently Married, Previously Treated and Previously Untreated showed no statistical significance at p>0.05. This study identified Female Sex, Rural Residence, and Age (26-45 years) as risk factors for MDR-TB among HIV-infected patients in Northwestern Nigeria. We recommend a prospective study for further understanding of the clinical outcomes of TB treatment and disease.},
year = {2022}
}
TY - JOUR T1 - Risk Factors for Multidrug-Resistant Tuberculosis (MDR-TB) Among Human Immunodeficiency Virus (HIV)-Infected Patients in Northwestern Nigeria AU - Egbenoma Andrew Aigboeghian AU - Simon Ikechukwu Enem AU - Preciousgift Orhue Isibor Y1 - 2022/09/14 PY - 2022 N1 - https://doi.org/10.11648/j.wjph.20220703.14 DO - 10.11648/j.wjph.20220703.14 T2 - World Journal of Public Health JF - World Journal of Public Health JO - World Journal of Public Health SP - 119 EP - 123 PB - Science Publishing Group SN - 2637-6059 UR - https://doi.org/10.11648/j.wjph.20220703.14 AB - Multidrug-resistant tuberculosis (MDR-TB) is a major threat to tuberculosis (TB) control, and a common occurrence among HIV-infected patients in Nigeria. MDR-TB represents TB simultaneously resistant to at least rifampicin and isoniazid. This study aimed to identify the risk factors for MDR-TB among HIV-infected patients from four Northwestern Nigeria states attending treatment in Aminu Kano Teaching Hospital. A hospital-based retrospective case-control study was conducted by reviewing the clinical records of HIV-infected patients tested for MDR-TB from January 2015 to January 2017. A total of 111 MDR-TB cases were obtained, with equal number (111) of randomly selected controls for this study. We used a descriptive statistical technique to obtain summary values for cases and controls. Variables that showed significant association in bivariate analysis were subjected to multivariable logistic analysis. The independent predictors for MDR-TB were Female Sex (AOR=48.26, 95%, Cl: 6.39-365.88), Rural Residence (AOR=4.09, 95%, Cl: 2.05-8.17) and Age (26-45 years) (AOR=1.34, 95%, Cl: 0.56-3.59). Factors such as; Currently Married, Not Currently Married, Previously Treated and Previously Untreated showed no statistical significance at p>0.05. This study identified Female Sex, Rural Residence, and Age (26-45 years) as risk factors for MDR-TB among HIV-infected patients in Northwestern Nigeria. We recommend a prospective study for further understanding of the clinical outcomes of TB treatment and disease. VL - 7 IS - 3 ER -
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